Document Detail


Decreased expression of B7 costimulatory molecules and major histocompatibility complex class-I in human hepatocellular carcinoma.
MedLine Citation:
PMID:  15377288     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND AIM: We analyzed the expression of antigen-processing and antigen-presenting molecules in surgically resected fresh samples of human hepatocellular carcinoma (HCC) tissue to elucidate a mechanism of immune escape. We also examined the expression of interleukin (IL)-10 protein, which might act to downregulate expression of antigen-processing and antigen-presenting molecules. METHODS: Twenty-eight HCC samples obtained by surgical resection were analyzed for the expression of beta2-microglobulin, heat-shock protein (HSP)-70, human leukocyte antigen (HLA) class-I, CD80 (B7-1), CD86 (B7-2) and IL-10 by immunostaining. RESULTS: Beta2-microglobulin and HSP-70 were preserved in all samples. In contrast, the expression of HLA class-I molecules was significantly reduced according to lowering in the histological grading of tumor differentiation (P = 0.024). Furthermore, B7-1 and B7-2 expression was reduced in tumor cells compared with corresponding areas of liver tissue without malignant involvement irrespective of the histological grading of tumors (21% and 36%, respectively). Although IL-10 protein was expressed in 54% of HCC, no relationship between the expression of IL-10 and downregulation of B7-1, B7-2, and HLA class-I was evident. CONCLUSION: These findings suggest the potential role of B7 co-stimulatory molecules and HLA class-I molecules in facilitating HCC escape from immune surveillance without the involvement of IL-10.
Authors:
Keishi Fujiwara; Toshihiro Higashi; Kazuhiro Nouso; Harushige Nakatsukasa; Yoshiyuki Kobayashi; Masayuki Uemura; Shin-Ichiro Nakamura; Shuichiro Sato; Tadashi Hanafusa; Yasuhiro Yumoto; Ichiro Naito; Yasushi Shiratori
Related Documents :
3538548 - Immunoglobulin class and specificity of antibodies causing positive t cell crossmatches...
3261248 - Direct and indirect nickel-specific stimulation of t lymphocytes from patients with all...
12170258 - Defining antigen-specific responses with human mhc class ii tetramers.
2741648 - Induction of hla-dq antigen expression on a human promyelocytic leukemia cell line hl-60.
23300118 - Long-term measurement of anti-adalimumab using ph-shift-anti-idiotype antigen binding t...
7389198 - Intracerebral synthesis of antibodies to measles and distemper viruses in patients with...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  19     ISSN:  0815-9319     ISO Abbreviation:  J. Gastroenterol. Hepatol.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-09-20     Completed Date:  2005-03-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  1121-7     Citation Subset:  IM    
Affiliation:
Department of Medicine and Medical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Antigens, CD80 / biosynthesis*
Carcinoma, Hepatocellular / immunology*
Female
Genes, MHC Class I / immunology*
HSP70 Heat-Shock Proteins / biosynthesis,  immunology
Humans
Interleukin-10 / biosynthesis,  immunology
Liver Neoplasms / immunology*
Male
beta 2-Microglobulin / biosynthesis,  immunology
Chemical
Reg. No./Substance:
0/Antigens, CD80; 0/HSP70 Heat-Shock Proteins; 0/beta 2-Microglobulin; 130068-27-8/Interleukin-10

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Risk behaviors and antibody hepatitis B and C prevalence among injecting drug users in south-western...
Next Document:  Induction of cholestasis in the perfused rat liver by 2-aminoethyl diphenylborate, an inhibitor of t...