Document Detail

Decreased expression of B7 costimulatory molecules and major histocompatibility complex class-I in human hepatocellular carcinoma.
MedLine Citation:
PMID:  15377288     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIM: We analyzed the expression of antigen-processing and antigen-presenting molecules in surgically resected fresh samples of human hepatocellular carcinoma (HCC) tissue to elucidate a mechanism of immune escape. We also examined the expression of interleukin (IL)-10 protein, which might act to downregulate expression of antigen-processing and antigen-presenting molecules. METHODS: Twenty-eight HCC samples obtained by surgical resection were analyzed for the expression of beta2-microglobulin, heat-shock protein (HSP)-70, human leukocyte antigen (HLA) class-I, CD80 (B7-1), CD86 (B7-2) and IL-10 by immunostaining. RESULTS: Beta2-microglobulin and HSP-70 were preserved in all samples. In contrast, the expression of HLA class-I molecules was significantly reduced according to lowering in the histological grading of tumor differentiation (P = 0.024). Furthermore, B7-1 and B7-2 expression was reduced in tumor cells compared with corresponding areas of liver tissue without malignant involvement irrespective of the histological grading of tumors (21% and 36%, respectively). Although IL-10 protein was expressed in 54% of HCC, no relationship between the expression of IL-10 and downregulation of B7-1, B7-2, and HLA class-I was evident. CONCLUSION: These findings suggest the potential role of B7 co-stimulatory molecules and HLA class-I molecules in facilitating HCC escape from immune surveillance without the involvement of IL-10.
Keishi Fujiwara; Toshihiro Higashi; Kazuhiro Nouso; Harushige Nakatsukasa; Yoshiyuki Kobayashi; Masayuki Uemura; Shin-Ichiro Nakamura; Shuichiro Sato; Tadashi Hanafusa; Yasuhiro Yumoto; Ichiro Naito; Yasushi Shiratori
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  19     ISSN:  0815-9319     ISO Abbreviation:  J. Gastroenterol. Hepatol.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-09-20     Completed Date:  2005-03-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  1121-7     Citation Subset:  IM    
Department of Medicine and Medical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan.
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MeSH Terms
Antigens, CD80 / biosynthesis*
Carcinoma, Hepatocellular / immunology*
Genes, MHC Class I / immunology*
HSP70 Heat-Shock Proteins / biosynthesis,  immunology
Interleukin-10 / biosynthesis,  immunology
Liver Neoplasms / immunology*
beta 2-Microglobulin / biosynthesis,  immunology
Reg. No./Substance:
0/Antigens, CD80; 0/HSP70 Heat-Shock Proteins; 0/beta 2-Microglobulin; 130068-27-8/Interleukin-10

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