Document Detail


Decreased exhaled nitric oxide levels in patients with mitochondrial disorders.
MedLine Citation:
PMID:  23935767     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Nitric oxide (NO) deficiency may occur in mitochondrial disorders (MD) and can contribute to the pathogenesis of the disease. It is difficult and invasive to measure systemic nitric oxide. NO is formed in the lungs and can be detected in expired air. Currently, hand-held fractional exhaled nitric oxide (FeNO) measurement devices are available enabling a fast in-office analysis of this non-invasive test. It was postulated that FeNO levels might be reduced in MD.
METHODS: Sixteen subjects with definite MD by modified Walker criteria (4 to 30 years of age) and sixteen healthy control subjects of similar age, race and body mass index (BMI) underwent measurement of FeNO in accordance with the American Thoracic Society guidelines.
RESULTS: Sixteen patient-control pairs were recruited. The median FeNO level was 6.5 ppm (IQR: 4-9.5) and 10.5 ppm (IQR: 8-20.5) in the MD and control groups, respectively. In 13 pairs (81%), the FeNO levels were lower in the MD cases than in the matched controls (p=0.021). Eleven (69%) cases had very low FeNO levels (≤7ppm) compared to only 1 control (p=0.001). All cases with enzymatic deficiencies in complex I had FeNO ≤7ppm.
CONCLUSIONS: Single-breath exhaled nitric oxide recordings were decreased in patients with MD. This pilot study suggests that hand-held FeNO measurements could be an attractive non-invasive indicator of MD. In addition, measurement of FeNO could be used as a parameter to monitor therapeutic response in this population.
Authors:
Ricardo A Mosquera; Cheryl L Samuels; Tomika S Harris; Aravind Yadav; S Shahrukh Hashmi; Melissa S Knight; Mary Kay Koenig
Related Documents :
21535817 - Contents of phenolics and flavonoids and antioxidant activities in skin, pulp, and seed...
21839647 - Fluorescence properties and antiproliferative effects of mono-, bis-, and tris- thiophe...
6245447 - Widespread occurrence in frogs and toads of skin compounds interacting with the ouabain...
21985227 - A new flavan-3-ol and the anti-inflammatory effect of flavonoids from the fruit peels o...
17521697 - Redox reactions in the fe-as-o2 system.
23678997 - The dimethoxyphenylbenzyl protecting group: an alternative to the p-methoxybenzyl group...
Publication Detail:
Type:  Journal Article     Date:  2013-07-26
Journal Detail:
Title:  The open respiratory medicine journal     Volume:  7     ISSN:  1874-3064     ISO Abbreviation:  Open Respir Med J     Publication Date:  2013  
Date Detail:
Created Date:  2013-08-12     Completed Date:  2013-08-12     Revised Date:  2013-08-14    
Medline Journal Info:
Nlm Unique ID:  101480481     Medline TA:  Open Respir Med J     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  67-70     Citation Subset:  -    
Affiliation:
University of Texas Health Science Center at Houston (UTHealth), School of Medicine, Department of Pediatric Pulmonary, Houston, Texas, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Impact of blood cultures on the changes of treatment in hospitalized patients with community-acquire...
Next Document:  Employment Status, Quality of Matching, and Retirement in Korea: Evidence from Korean Longitudinal S...