Document Detail

Decreased exercise muscle lactate release after high altitude acclimatization.
MedLine Citation:
PMID:  2793749     Owner:  NLM     Status:  MEDLINE    
Blood lactate concentration during exercise decreases after acclimatization to high altitude, but it is not clear whether there is decreased lactate release from the exercising muscle or if other mechanisms are involved. We measured iliac venous and femoral arterial lactate concentrations and iliac venous blood flow during cycle exercise before and after acclimatization to 4,300 m. During hypoxia, at a given O2 consumption the venous and arterial lactate concentrations, the venous and arterial concentration differences, and the net lactate release were lower after acclimatization than during acute altitude exposure. While breathing O2-enriched air after acclimatization at a given O2 consumption the venous and arterial lactate concentrations and the venous and arterial concentration differences were significantly lower, and the net lactate release tended to be lower than while breathing ambient air at sea level before acclimatization. We conclude that the lower lactate concentration in venous and arterial blood during exercise after altitude acclimatization reflected less net release of lactate by the exercising muscles, and that this likely resulted from the acclimatization process itself rather than the hypoxia per se.
P R Bender; B M Groves; R E McCullough; R G McCullough; L Trad; A J Young; A Cymerman; J T Reeves
Related Documents :
17286209 - The declining phase of lactation: peripheral or central, programmed or pathological?
2793749 - Decreased exercise muscle lactate release after high altitude acclimatization.
24793899 - Left ventricular torsion during exercise in patients with and without ischemic response...
7455889 - Postoperative exercise capacity following nutritional support with hypotonic glucose.
19650379 - Specific circuit training in young judokas: effects of rest duration.
871279 - Correlates of maximal oxygen consumption during treadmill exercise.
21178129 - Older type 2 diabetic males do not exhibit abnormal pulmonary oxygen uptake and muscle ...
12399019 - Stabilization of s-adenosyl-l-methionine promoted by trehalose.
16030079 - A randomized clinical trial of an individualized home-based exercise programme for wome...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  67     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1989-11-21     Completed Date:  1989-11-21     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1456-62     Citation Subset:  IM; S    
Cardiovascular Pulmonary Research Laboratory, University of Colorado Health Sciences Center, Denver 80262.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acclimatization / physiology*
Anoxia / metabolism
Exercise / physiology*
Femoral Artery
Iliac Vein
Lactates / blood*
Lactic Acid
Muscles / metabolism*
Oxygen Consumption / physiology
Grant Support
Reg. No./Substance:
0/Lactates; 50-21-5/Lactic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Respiratory sinus arrhythmia in the denervated human heart.
Next Document:  Nafamstat mesilate attenuates pulmonary hypertension in heparin-protamine reactions.