Document Detail


Decreased erythrocyte deformability in Behçet's disease.
MedLine Citation:
PMID:  16151256     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Behçet's disease (BD) is a chronic recurrent systemic vasculitis of unknown cause. Thrombotic tendency is another characteristics of BD. While hemorheological changes play crucial role in thrombosis, erythrocyte deformability (ED), which is one of the main determinants of microcirculation and blood viscosity, has not been studied before in BD. ED was measured by the filtration method in 13 active BD patients diagnosed according to the criteria proposed by International Study Group for BD (ISG-BD) and in 13 age-, sex-, weight-, smoking habit-, and blood pressure-matched healthy controls. ED was decreased in active BD patients compared to the healthy control subjects. The median deformability indices (DIs) in BD patients and healthy controls were 3.19 and 2.08 (p<0.001), respectively. The decrease in ED may be one of the reasons for increased thrombotic tendency in BD. Alteration in ED possibly plays a crucial role in the etiopathogenesis of thrombotic complications in BD and thus may be a target for treatment. Drugs increasing ED, such as pentoxifylline, have already been shown to be beneficial in the treatment of BD. Therefore, we propose that the therapeutic mechanism underlying the beneficial effect of this drug in BD is likely to be the correction of impaired ED.
Authors:
Oğuz Usküdar; Ayşen Erdem; Halûk Demiroğlu; Neslihan Dikmenoğlu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical hemorheology and microcirculation     Volume:  33     ISSN:  1386-0291     ISO Abbreviation:  Clin. Hemorheol. Microcirc.     Publication Date:  2005  
Date Detail:
Created Date:  2005-09-09     Completed Date:  2005-12-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9709206     Medline TA:  Clin Hemorheol Microcirc     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  89-94     Citation Subset:  IM    
Affiliation:
Department of Hematology, Hacettepe University Faculty of Medicine, Ankara, Turkey. ouskudar@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Behcet Syndrome / blood*,  complications,  etiology
Case-Control Studies
Erythrocyte Deformability*
Female
Humans
Male
Middle Aged
Pentoxifylline / pharmacology
Thrombosis / etiology
Chemical
Reg. No./Substance:
6493-05-6/Pentoxifylline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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