| Decreased dopamine transporter binding in Machado-Joseph disease. | |
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MedLine Citation:
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PMID: 10855623 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to use 99mTc-TRODAT-1 brain SPECT for investigation of the binding of dopamine transporter (DAT) in the nigrostriatal dopaminergic pathway of symptomatic Machado-Joseph disease (MJD) and to compare the results with the abnormal cytidylate, adenylate, and guanylate (CAG) expansion in the MJD1 gene and other clinical factors. METHODS: Ten symptomatic MJD patients (8 women, 2 men; age range, 20-71 y; mean age +/- SD, 36.4 +/- 10.6 y; mean duration of illness, 9.8 +/- 5.4 y) and 21 healthy volunteers (age range, 24-71 y; mean age, 47.6 +/- 20.1 y) were examined. Brain SPECT images were acquired 4 h after injection. The ratio of specific to nonspecific nigrostriatal 99mTc-TRODAT-1 binding was measured and compared with the clinical symptoms, duration of illness, and size of abnormal expanded CAG repeats. RESULTS: All nigrostriatal 99mTc-TRODAT-1 ratios were significantly lower in MJD patients than in healthy volunteers (P < 0.05). Discriminant function analysis of all MJD patients showed that the decreased binding of 99mTc-TRODAT-1 in the putamen was not significantly different from that in the caudate nucleus. Eight of 10 MJD patients had significantly decreased 99mTc-TRODAT-1 uptake. Of these 8, 2 had extrapyramidal signs and 6 had no obvious extrapyramidal signs. The other 2 patients, who had normal 99mTc-TRODAT-1 uptake, had no obvious extrapyramidal signs. CONCLUSION: Our findings indicate that 99mTc-TRODAT-1 brain SPECT is an appropriate method for evaluating damage to the nigrostriatal DAT in symptomatic MJD patients with and without extrapyramidal signs. The decreased binding of 99mTc-TRODAT-1 in the nigrostriatal dopaminergic pathway in symptomatic MJD patients correlates with the phenotype of extrapyramidal signs but not with the abnormal CAG repeat length, age at disease onset, or disease duration. |
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Authors:
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T C Yen; C S Lu; K Y Tzen; S P Wey; Y H Chou; Y H Weng; P F Kao; G Ting |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 41 ISSN: 0161-5505 ISO Abbreviation: J. Nucl. Med. Publication Date: 2000 Jun |
Date Detail:
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Created Date: 2000-07-07 Completed Date: 2000-07-07 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 994-8 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine, Chang Gung Memorial Hospital, Taipei Medical Center and School of Medicine, Chang Gung University, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Brain / metabolism*, radionuclide imaging Carrier Proteins / metabolism* Caudate Nucleus / metabolism, radionuclide imaging Child Dopamine / metabolism* Dopamine Plasma Membrane Transport Proteins Female Humans Machado-Joseph Disease / metabolism*, radionuclide imaging Male Membrane Glycoproteins* Membrane Transport Proteins* Middle Aged Nerve Tissue Proteins* Organotechnetium Compounds / diagnostic use Putamen / metabolism, radionuclide imaging Substantia Nigra / metabolism Tomography, Emission-Computed, Single-Photon* Trinucleotide Repeat Expansion Tropanes / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/Dopamine Plasma Membrane Transport Proteins; 0/Membrane Glycoproteins; 0/Membrane Transport Proteins; 0/Nerve Tissue Proteins; 0/Organotechnetium Compounds; 0/SLC6A3 protein, human; 0/Tropanes; 0/technetium Tc 99m TRODAT-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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