Document Detail


Decreased density of serotonin 2A receptors in the superior temporal gyrus in schizophrenia-a postmortem study.
MedLine Citation:
PMID:  19389456     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
The superior temporal gyrus (STG) is strongly implicated in the pathophysiology of schizophrenia, particularly with regards to auditory hallucinations. In this study, using in situ quantitative autoradiography in postmortem tissue, we investigated the binding of the [3H]ketanserin to 5-HT(2A) receptors and [3H]mesulergine to 5-HT(2C) receptors in the left STG of 8 male schizophrenic patients compared to 8 control subjects. A strong [3H]ketanserin binding was observed in the STG, however there was a very weak [3H]mesulergine binding in the STG. A significant decrease in binding of [(3)H]ketanserin was clearly observed in schizophrenia patients in comparison with control subjects. There were no significant correlations between 5-HT(2A) binding density and age, postmortem intervals, or brain pH. These results suggest that the alterations of the 5-HT(2A) receptors contribute to the pathophysiology of the STG in schizophrenia. Furthermore, there is a clear tendency for a positive correlation between 5-HT(2A) and muscarinic M1 receptor bindings, and for negative correlations between 5-HT(2A) and GABA(A) receptor bindings and between muscarinic M1 and GABA(A) receptor bindings. This provides a possible mechanism of auditory hallucinations through interactions between 5-HT(2A), acetylcholine muscarinic and GABA transmissions in the STG in schizophrenia.
Authors:
Kai Kang; Xu-Feng Huang; Qing Wang; Chao Deng
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-04-21
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  33     ISSN:  1878-4216     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  867-71     Citation Subset:  IM    
Affiliation:
Centre for Translational Neuroscience, School of Health Sciences, University of Wollongong, Wollongong, NSW 2522, Australia.
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Comment In:
Prog Neuropsychopharmacol Biol Psychiatry. 2009 Nov 13;33(8):1583-4; author reply 1585-6   [PMID:  19699251 ]

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