Document Detail

Decreased cortical octopamine level in basal forebrain lesioned rats: a microdialysis study.
MedLine Citation:
PMID:  7685868     Owner:  NLM     Status:  MEDLINE    
Ibotenic acid-induced lesion of the basal forebrain resulted after 13 days in a 90% reduction of octopamine (OA) in the frontoparietal cortex of adult rats, whereas dihydroxyphenylacetic (DOPAC), homovanillic (HVA) and 5-hydroxyindoleacetic (5-HIAA) acids were not modified as measured by microdialysis and high-performance liquid chromatography (HPLC) with electrochemical detection. At this time, cortical choline acetyltransferase (ChAT) activity was decreased by 34%. The results are discussed with respect to possible octopamine involvement in reduced age-associated performance in neurodegenerative processes.
G Bendahan; M L Boatell; N Mahy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience letters     Volume:  152     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-07-19     Completed Date:  1993-07-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  45-7     Citation Subset:  IM    
Unit of Biochemistry, School of Medicine, University of Barcelona, Spain.
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MeSH Terms
3,4-Dihydroxyphenylacetic Acid / metabolism
Choline O-Acetyltransferase / metabolism
Chromatography, High Pressure Liquid
Frontal Lobe / metabolism*
Homovanillic Acid / metabolism
Hydroxyindoleacetic Acid / metabolism
Ibotenic Acid / toxicity
Octopamine / metabolism*
Parietal Lobe / metabolism*
Prosencephalon / drug effects*,  metabolism
Rats, Sprague-Dawley
Reg. No./Substance:
102-32-9/3,4-Dihydroxyphenylacetic Acid; 104-14-3/Octopamine; 2552-55-8/Ibotenic Acid; 306-08-1/Homovanillic Acid; 54-16-0/Hydroxyindoleacetic Acid; EC O-Acetyltransferase

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