Document Detail


Decreased circulating miRNA levels in patients with primary progressive multiple sclerosis.
MedLine Citation:
PMID:  24277735     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Emerging evidence underlines the importance of micro(mi)RNAs in the pathogenesis of multiple sclerosis (MS). Free-circulating miRNAs were investigated in serum from MS patients compared to controls. Statistically significant decreased levels of miR-15b, miR-23a and miR-223 were observed in MS patients (p < 0.05). Results were validated and replicated in two further independent MS populations. A direct correlation between miRNA levels and the EDSS score was determined in PPMS (p < 0.007). The generalized trend toward miRNA down-regulation could result in over-expression of target genes involved in disease pathogenesis. Circulating miRNA profiling could thus represent a new avenue to identify easily detectable disease biomarkers.
Authors:
Chiara Fenoglio; Elisa Ridolfi; Claudia Cantoni; Milena De Riz; Rossana Bonsi; Maria Serpente; Chiara Villa; Anna M Pietroboni; Robert T Naismith; Enrique Alvarez; Becky J Parks; Nereo Bresolin; Anne H Cross; Laura M Piccio; Daniela Galimberti; Elio Scarpini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Multiple sclerosis (Houndmills, Basingstoke, England)     Volume:  19     ISSN:  1477-0970     ISO Abbreviation:  Mult. Scler.     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2013-11-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9509185     Medline TA:  Mult Scler     Country:  England    
Other Details:
Languages:  eng     Pagination:  1938-42     Citation Subset:  IM    
Affiliation:
Department of Pathophysiology and Transplantation "Dino Ferrari" Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Italy.
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