Document Detail

Decreased cholestasis with enteral instead of intravenous protein in the very low-birth-weight infant.
MedLine Citation:
PMID:  2506323     Owner:  NLM     Status:  MEDLINE    
Thirty to 50% of very low-birth-weight infants have parenteral nutrition-associated cholestasis. To test the hypothesis that the incidence of cholestasis would be decreased if parenteral amino acids were avoided and protein given enterally, infants with a gestational age of less than 30 weeks were randomized to two groups. One group received amino acid-free parenteral nutrition and whey protein enterally with added premature infant formula. The control group received standard parenteral nutrition with amino acids and enteral premature formula. At the end of 3 weeks of parenteral nutrition, infants who had a direct serum bilirubin level of greater than 3 mg/dl were considered to have significant cholestasis. Twenty-nine infants required parenteral nutrition for 3 weeks, 17 in the whey group and 12 in the control group. No instances of significant cholestasis were observed in the whey group (0/17), whereas seven of 12 infants (58%) in the amino acid control group had cholestasis (p less than 0.001).
M R Brown; B J Thunberg; L Golub; W M Maniscalco; C Cox; D L Shapiro
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  9     ISSN:  0277-2116     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-10-25     Completed Date:  1989-10-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  21-7     Citation Subset:  IM    
Department of Pediatrics, Strong Memorial Hospital, University of Rochester Medical Center, New York 14642.
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MeSH Terms
Amino Acids / administration & dosage
Cholestasis / etiology,  prevention & control*
Enteral Nutrition*
Evaluation Studies as Topic
Infant, Low Birth Weight / metabolism*
Infant, Newborn
Parenteral Nutrition, Total / adverse effects*
Proteins / administration & dosage*
Reg. No./Substance:
0/Amino Acids; 0/Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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