Document Detail

Decreased cholecystokinin levels in cerebrospinal fluid of patients with adult chronic hydrocephalus syndrome.
MedLine Citation:
PMID:  9084899     Owner:  NLM     Status:  MEDLINE    
Cholecystokinin (CCK) levels were measured in cerebrospinal fluid (CSF) of patients with adult chronic hydrocephalus syndrome (ACHS) (n = 16) and compared with levels from a control group (n = 11). The CSF concentration of CCK in the ACHS group (0.79 +/- 0.53 fmol/mL) was significantly reduced (p = .002) with respect to the controls (1.55 +/- 0.54 fmol/mL). As CCK-8, the most prevalent from of CCK in the central nervous system, has been demonstrated to play a significant role in several physiological and behavioral actions, the reduced octapeptide values found in ACHS could be involved in the disturbances associated with this disorder. Continuous monitoring of intracranial pressure (ICP) demonstrated different ICP profiles in ACHS. We found that all patients with abnormal ICP records except one showed CCK values under the detection limit. Three of the 4 patients with normal ICP had CCK levels within the normal range. These preliminary studies could evidence that ICP alterations are responsible for part of the loss of brain neuropeptide levels in ACHS.
R Galard; M A Poca; R Catalán; M Tintoré; J M Castellanos; J Sahuquillo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological psychiatry     Volume:  41     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-06-25     Completed Date:  1997-06-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  804-9     Citation Subset:  IM    
Department of Biochemistry, Vall d'Hebron University Hospitals, Barcelona, Spain.
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MeSH Terms
Cholecystokinin / cerebrospinal fluid*
Chronic Disease
Hydrocephalus, Normal Pressure / cerebrospinal fluid*,  diagnosis
Intracranial Pressure / physiology
Middle Aged
Monitoring, Physiologic
Neurologic Examination
Reference Values
Sincalide / cerebrospinal fluid
Reg. No./Substance:
25126-32-3/Sincalide; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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