| Decreased cerebrospinal fluid absorption during abdominal insufflation. | |
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MedLine Citation:
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PMID: 10430688 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Intracranial pressure (ICP) is known to rise during induced CO(2) pneumoperitoneum. This rise correlates with an increase in inferior vena caval pressure; therefore, it is probably associated with increased pressure in the lumbar venous plexus. Branches of this plexus communicate with arachnoid villi in the lumbar cistern and the dural sleeves of spinal nerve roots-areas where cerebrospinal fluid (CSF) absorption to normally takes place. The increased venous pressure in this area may impede CSF absorption. Because CSF is produced at a constant rate, decreased absorption will increase ICP. We hypothesized that increased ICP occurring during abdominal insufflation is due, at least in part, to decreased absorption of CSF. The purpose of this study is to show that CSF absorption is inhibited during abdominal insufflation. METHODS: After appropriate approval was obtained, 16 domestic swine were anesthetized and injected into the CSF with 100 microcuries (microCu) of I(131) radioactive iodinated human serum albumin (RISA) in 2 ml of normal saline. Eight subjects underwent CO(2) abdominal insufflation to 15 mmHg and were maintained for 4 h. A control group did not undergo insufflation. Blood levels of RISA were measured over a 4-h period to determine the rate of CSF absorption. RESULTS: Blood levels of RISA increased at a slower rate in the subjects undergoing abdominal insufflation than in the control group. The mean change over 2 h in the insufflated group was 15% compared to 34% in the control group (p = 0.02). This difference indicates decreased absorption of CSF in the insufflated group. CONCLUSIONS: These results demonstrate decreased absorption of CSF during abdominal insufflation and support the hypothesis that the increase in ICP pressure occurring during abdominal insufflation is caused, at least in part, by decreased absorption of CSF in the region of the lumbar cistern and the dural sleeves of spinal nerve roots. |
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Authors:
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A L Halverson; W L Barrett; A R Iglesias; W T Lee; S M Garber; J M Sackier |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Surgical endoscopy Volume: 13 ISSN: 0930-2794 ISO Abbreviation: Surg Endosc Publication Date: 1999 Aug |
Date Detail:
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Created Date: 1999-08-10 Completed Date: 1999-08-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8806653 Medline TA: Surg Endosc Country: GERMANY |
Other Details:
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Languages: eng Pagination: 797-800 Citation Subset: IM |
Affiliation:
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Washington Institute of Surgical Endoscopy, The George Washington University, 2150 Pennsylvania Avenue, N.W., 6B-412, Washington, DC 20037, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cerebrospinal Fluid / physiology* Intracranial Pressure* Pneumoperitoneum, Artificial* Radiopharmaceuticals / diagnostic use Serum Albumin, Radio-Iodinated / diagnostic use Swine |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 0/Serum Albumin, Radio-Iodinated |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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