| Decreased cellular IL-23 but not IL-17 production in children with autism spectrum disorders. | |
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MedLine Citation:
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PMID: 19800697 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A potential role for T(H)17 cells has been suggested in a number of conditions including neurodevelopmental disorders such as autism spectrum disorders (ASD). In the current study, we investigated cellular release of IL-17 and IL-23 following an in-vitro immunological challenge of peripheral blood mononuclear cells (PBMC) from children with ASD compared to age-matched typically developing controls. Following stimulation, the concentration of IL-23, but not IL-17, was significantly reduced (p=0.021) in ASD compared to controls. Decreased cellular IL-23 production in ASD warrants further research to determine its role on the generation and survival of T(H)17 cells, a cell subset important in neuroinflammatory conditions that may include ASD. |
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Authors:
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Charity Onore; Amanda Enstrom; Paula Krakowiak; Irva Hertz-Picciotto; Robin Hansen; Judy Van de Water; Paul Ashwood |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-10-02 |
Journal Detail:
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Title: Journal of neuroimmunology Volume: 216 ISSN: 1872-8421 ISO Abbreviation: J. Neuroimmunol. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-17 Completed Date: 2010-01-11 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 8109498 Medline TA: J Neuroimmunol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 126-9 Citation Subset: IM |
Affiliation:
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Department of Medical Microbiology and Immunology, University of California at Davis, USA. pashwood@ucdavis.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Autistic Disorder
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immunology*,
metabolism*,
physiopathology Biological Markers / metabolism Cells, Cultured Child, Preschool Down-Regulation / drug effects, immunology Encephalitis / complications, immunology, physiopathology Female Humans Interleukin-17 / metabolism* Interleukin-23 / metabolism* Leukocytes, Mononuclear / immunology*, metabolism* Male Neuropsychological Tests Phytohemagglutinins / diagnostic use, immunology, pharmacology Questionnaires Social Behavior Social Behavior Disorders / diagnosis, immunology T-Lymphocytes, Helper-Inducer / drug effects, immunology |
| Grant Support | |
ID/Acronym/Agency:
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P01 ES011269/ES/NIEHS NIH HHS; P01 ES011269-060004/ES/NIEHS NIH HHS; R01 ES015359/ES/NIEHS NIH HHS; R01 ES015359-05/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Interleukin-17; 0/Interleukin-23; 0/Phytohemagglutinins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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