| Decreased blood serotonin in the premenstrual phase enhances negative mood in healthy women. | |
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MedLine Citation:
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PMID: 20384471 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to evaluate mechanisms underlying the action of selective serotonin reuptake inhibitors on the improvement of negative mood symptoms in premenstrual syndrome. We assessed relationships between serotonin (5-HT) levels in the brain (estimated from 5-HT concentrations in whole blood) and negative mood states during the premenstrual phase in 13 healthy women. Mood states were evaluated using the Profile of Mood States questionnaire. We also evaluated relationships between 5-HT and ovarian hormones (oestradiol and progesterone). A significant negative correlation was seen between 5-HT concentrations in whole blood and negative mood scores (tension-anxiety and fatigue) observed in the premenstrual phase. A significant positive correlation was observed between 5-HT and oestradiol in the premenstrual phase, but not in the follicular phase. These results suggest that healthy women with lower whole blood 5-HT concentrations in the premenstrual phase exhibit enhanced negative mood due to lower 5-HT concentrations at brain synapses, which may be caused in part by lower oestrogen concentration. |
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Authors:
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Hiromi Kikuchi; Yasushi Nakatani; Yoshinari Seki; Xinjun Yu; Tamami Sekiyama; Ikuko Sato-Suzuki; Hideho Arita |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of psychosomatic obstetrics and gynaecology Volume: 31 ISSN: 1743-8942 ISO Abbreviation: J Psychosom Obstet Gynaecol Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-06 Completed Date: 2010-08-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8308648 Medline TA: J Psychosom Obstet Gynaecol Country: England |
Other Details:
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Languages: eng Pagination: 83-9 Citation Subset: IM |
Affiliation:
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Department of Physiology, Toho University School of Medicine, Ota-ku, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Affect / physiology* Brain / metabolism Estradiol / blood Female Follicular Phase / blood Humans Personality Inventory Premenstrual Syndrome / blood*, diagnosis, psychology Progesterone / blood Reference Values Serotonin / blood* |
| Chemical | |
Reg. No./Substance:
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50-28-2/Estradiol; 50-67-9/Serotonin; 57-83-0/Progesterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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