Document Detail

Decreased blood serotonin in the premenstrual phase enhances negative mood in healthy women.
MedLine Citation:
PMID:  20384471     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to evaluate mechanisms underlying the action of selective serotonin reuptake inhibitors on the improvement of negative mood symptoms in premenstrual syndrome. We assessed relationships between serotonin (5-HT) levels in the brain (estimated from 5-HT concentrations in whole blood) and negative mood states during the premenstrual phase in 13 healthy women. Mood states were evaluated using the Profile of Mood States questionnaire. We also evaluated relationships between 5-HT and ovarian hormones (oestradiol and progesterone). A significant negative correlation was seen between 5-HT concentrations in whole blood and negative mood scores (tension-anxiety and fatigue) observed in the premenstrual phase. A significant positive correlation was observed between 5-HT and oestradiol in the premenstrual phase, but not in the follicular phase. These results suggest that healthy women with lower whole blood 5-HT concentrations in the premenstrual phase exhibit enhanced negative mood due to lower 5-HT concentrations at brain synapses, which may be caused in part by lower oestrogen concentration.
Hiromi Kikuchi; Yasushi Nakatani; Yoshinari Seki; Xinjun Yu; Tamami Sekiyama; Ikuko Sato-Suzuki; Hideho Arita
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of psychosomatic obstetrics and gynaecology     Volume:  31     ISSN:  1743-8942     ISO Abbreviation:  J Psychosom Obstet Gynaecol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-06     Completed Date:  2010-08-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8308648     Medline TA:  J Psychosom Obstet Gynaecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  83-9     Citation Subset:  IM    
Department of Physiology, Toho University School of Medicine, Ota-ku, Tokyo, Japan.
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MeSH Terms
Affect / physiology*
Brain / metabolism
Estradiol / blood
Follicular Phase / blood
Personality Inventory
Premenstrual Syndrome / blood*,  diagnosis,  psychology
Progesterone / blood
Reference Values
Serotonin / blood*
Reg. No./Substance:
50-28-2/Estradiol; 50-67-9/Serotonin; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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