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Decreased blood pressure with corresponding decrease in adhesive molecules in diabetic rats caused by vitamin E administration.
MedLine Citation:
PMID:  22236396     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective:  Hypertension is one of the important clinical problems of the diabetic cardiovascular disease. The aim of this study was to determine the effect of vitamin E on blood pressure parameters and adhesive molecule amounts in diabetic rat. Methods:  Twenty-four male Wistar rats were divided into three groups (n=8) Control(C), non-treated diabetic (NTD) and vitamin E treated diabetic (VETD) groups. Single IP injection of buffered STZ (60mg/kg) in cold sodium citrate (pH 4.5) was used to induce diabetes. The VETD was received 300mg of vitamin E daily intragastrically for 6 weeks. Systolic, diastolic, mean arterial pressure as well as dicrotic pressure, crests time, systolic and diastolic period and plasma levels of ICAM-1 and E-selectin were measured after 6 weeks. Results:  The results revealed that along with significant increase systolic, diastolic, mean arterial pressure, crest time, systolic duration, and the amount of VCAM-1 and E-selectin in diabetic rats. There was no significant difference in heart rate, and cardiac cyclic duration among different groups. Significant improvement of blood pressure parameters as well as attenuation of the elevated VCAM-1 and E-selectin amounts was found in vitamin E treated group. Conclusions:  These finding indicate that vitamin E significantly improved blood pressure elevation in diabetic rats and that these effects could be associated with reducing adhesive molecule and antioxidant properties of vitamin E.
Authors:
Alireza Shirpoor; Mohammad-Hasan Khadem Ansari; Behnam Heshmatian; Behrouz Ilkhanizadeh; Leila Noruzi; Naseh Abdollahzadeh; Ehsan Saboory
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-11
Journal Detail:
Title:  Journal of diabetes     Volume:  -     ISSN:  1753-0407     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101504326     Medline TA:  J Diabetes     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Ruijin Hospital and Blackwell Publishing Asia Pty Ltd.
Affiliation:
Department of Physiology, Faculty of Medicine, Urmia Medical University, Urmia, Iran Department of Biochemistry, Faculty of Medicine, Urmia Medical University, Urmia, Iran Department of Pathology, Faculty of Medicine, Urmia Medical University, Urmia, Iran.
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