Document Detail

Decreased biosynthesis of glycosaminoglycans in the skin of rats with chronic diabetes mellitus.
MedLine Citation:
PMID:  10334465     Owner:  NLM     Status:  MEDLINE    
The skin of rats with experimental (streptozotocin-induced) chronic diabetes mellitus exhibits significant decrease in glycosaminoglycans (GAGs) content. In the present study we asked the question whether the decrease in GAGs content is a result of decline in GAG biosynthesis or an increase in their degradation. We demonstrated by a pulse-labeling experiments that diabetes results in a decrease of [14C]-glucosamine incorporation into both hyaluronic acid and sulphated GAGs. During the chase period, there was no significant degradation of the pulse-labeled GAGs, suggesting that the reduction of GAGs content in the skin of diabetic rats is a result of decrease in GAG biosynthesis. Especially the biosynthesis of sulphated GAGs is deeply reduced. This phenomenon may be one of the factors which impairs the wound healing in diabetic subjects.
M Cechowska-Pasko; J Pałka; E Bańkowski
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie     Volume:  51     ISSN:  0940-2993     ISO Abbreviation:  Exp. Toxicol. Pathol.     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-06-25     Completed Date:  1999-06-25     Revised Date:  2006-10-30    
Medline Journal Info:
Nlm Unique ID:  9208920     Medline TA:  Exp Toxicol Pathol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  239-43     Citation Subset:  IM    
Department of Biochemistry, Medical Academy of Białystok, Poland.
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MeSH Terms
Carbon Radioisotopes / diagnostic use
Chronic Disease
Diabetes Mellitus, Experimental / metabolism*
Glucosamine / metabolism
Glycosaminoglycans / biosynthesis*
Hyaluronic Acid / metabolism
Rats, Wistar
Skin / metabolism*
Sulfates / metabolism
Sulfur Radioisotopes / diagnostic use
Time Factors
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Glycosaminoglycans; 0/Sulfates; 0/Sulfur Radioisotopes; 3416-24-8/Glucosamine; 9004-61-9/Hyaluronic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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