Document Detail

Decreased beta-adrenergic stimulation of glycoprotein secretion in CF mice submandibular glands: reversal by the methylxanthine, IBMX.
MedLine Citation:
PMID:  7488008     Owner:  NLM     Status:  MEDLINE    
beta-adrenergic stimulation of glycoprotein secretion was shown to be decreased in submandibular glands of Cystic Fibrosis (CF) mice. The defective response was partially restored by the methylxanthine, IBMX or cpt-cyclic AMP. Cholinergic stimulation of pancreatic amylase secretion was not affected in CF mice, demonstrating that this is not a generalised depression of protein secretion. The data are the first to show that the CF mouse mimics the protein secretion defect in CF human submandibular cells and that the mechanism of correction of the CF defect is via elevation of cyclic AMP. The results are therefore invaluable towards devising a rational pharmaceutical therapy for CF patients.
C L Mills; J R Dorin; D J Davidson; D J Porteus; E W Alton; R L Dormer; M A McPherson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  215     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1995-11-24     Completed Date:  1995-11-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  674-81     Citation Subset:  IM    
Department of Medical Biochemistry, University of Wales College of Medicine, U.K.
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MeSH Terms
1-Methyl-3-isobutylxanthine / pharmacology*
Adrenergic beta-Agonists / pharmacology*
Amylases / secretion
Carbachol / pharmacology*
Cyclic AMP / analogs & derivatives,  metabolism,  pharmacology
Cystic Fibrosis / metabolism*
Glucosamine / metabolism
Glycoproteins / biosynthesis*
Mice, Mutant Strains
Pancreas / drug effects,  enzymology
Submandibular Gland / drug effects,  metabolism*
Thionucleotides / pharmacology
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Glycoproteins; 0/Thionucleotides; 28822-58-4/1-Methyl-3-isobutylxanthine; 3416-24-8/Glucosamine; 41941-66-6/8-((4-chlorophenyl)thio)cyclic-3',5'-AMP; 51-83-2/Carbachol; 60-92-4/Cyclic AMP; EC 3.2.1.-/Amylases

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