| Decreased arteriolar sensitivity to shear stress in adult rats is reversed by chronic exercise activity. | |
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MedLine Citation:
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PMID: 11932776 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We tested the hypothesis that the decline in endothelium-dependent arteriolar dilation in adult rats is reversed by chronic exercise activity. METHODS: Rats were divided into young (8-10 weeks)-sedentary (SED(Y)), adult (29-32 weeks)-sedentary (SED(A)), and adult-exercised (EX(A), treadmill exercise for 18-20 weeks) groups. Responses of isolated arterioles ( approximately 50 microm at 80 mm Hg) of gracilis muscle were assessed to increases in perfusate flow and vasoactive agents. RESULTS: With no differences in basal tone, maximal flow-induced dilations were not different between arterioles of SED(Y) and SED(A) rats (71 +/- 2 and 72 +/- 2% of passive diameter, respectively), yet the sensitivity of arterioles to shear stress (WSS(50)) was significantly less in SED(A) than in SED(Y) rats (35 +/- 4 vs. 23 +/- 3 dyne/cm(2), respectively). In vessels of EX(A) rats, maximal flow-induced dilation was significantly augmented (88 +/- 2% of passive diameter) and WSS(50) (15 +/- 1 dyn/cm(2)) was significantly reduced. Dilation to acetylcholine was enhanced in arterioles of EX(A), whereas dilation to sodium nitroprusside was not different in vessels of the three groups. CONCLUSION: Chronic exercise activity reverses age related reduction in sensitivity of arterioles to increases in wall shear stress. |
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Authors:
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Dong Sun; An Huang; Akos Koller; Gabor Kaley |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Microcirculation (New York, N.Y. : 1994) Volume: 9 ISSN: 1073-9688 ISO Abbreviation: Microcirculation Publication Date: 2002 Apr |
Date Detail:
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Created Date: 2002-04-04 Completed Date: 2002-11-12 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9434935 Medline TA: Microcirculation Country: United States |
Other Details:
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Languages: eng Pagination: 91-7 Citation Subset: IM |
Affiliation:
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Department of Physiology, New York Medical College, Valhalla, NY 10595, USA. Dong_Sun@nymc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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pharmacology Animals Arterioles / drug effects, physiology* Biomechanics Male Muscle, Skeletal / blood supply Nitroprusside / pharmacology Physical Exertion / physiology* Rats Rats, Wistar Vasodilation / drug effects, physiology |
| Grant Support | |
ID/Acronym/Agency:
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HL43023/HL/NHLBI NIH HHS; HL46813/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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15078-28-1/Nitroprusside; 51-84-3/Acetylcholine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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