| Decreased arterial dye-filling and venous dilation in the macular choroid associated with age-related macular degeneration. | |
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MedLine Citation:
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PMID: 15933588 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To compare the angioarchitecture of choroidal arteries and veins in patients with age-related macular degeneration (AMD) to the angioarchitecture of age-matched normal subjects using indocyanine green (ICG) angiography. METHODS: ICG angiography was performed in 35 consecutive AMD patients and 18 normal age-matched volunteers with a fundus ICG camera. ICG video images, including the arterial and venous phases, were quantitatively analyzed using image analyzing software. RESULTS: In patients with AMD, the choroidal arterioles are dilated, fewer, run a straighter course, and possess fewer bifurcations. The number of choroidal arteries and the macular fluorescent intensity in the arterial phase of choroidal filling was significantly less in patients with AMD as compared to age-matched normal controls (P = 0.008). The mean and maximum caliber of choroidal veins in the macula was dilated in AMD eyes than in age-matched normal control eyes (P < 0.001). There was no statistically significant difference in arterial dye filling or venous caliber observed in AMD eyes, with or without choroidal neovascular membrane (CNV). CONCLUSION: Choroidal arterial perfusion in the macula was significant decreased in eyes with AMD with and without CNV, and was associated with choroidal venous dilation. These observations implicate poor choroidal perfusion of the macula in the pathogenesis of AMD. |
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Authors:
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Keisuke Mori; Peter L Gehlbach; Yoko Nishiyama Ito; Shin Yoneya |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Retina (Philadelphia, Pa.) Volume: 25 ISSN: 0275-004X ISO Abbreviation: Retina (Philadelphia, Pa.) Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-06-03 Completed Date: 2005-08-02 Revised Date: 2006-12-15 |
Medline Journal Info:
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Nlm Unique ID: 8309919 Medline TA: Retina Country: United States |
Other Details:
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Languages: eng Pagination: 430-7 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Saitama Medical School, Iruma, Saitama, Japan. keisuke@saitama-med.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Arteries / pathology Capillary Permeability Case-Control Studies Choroid / blood supply* Choroidal Neovascularization / physiopathology* Coloring Agents / diagnostic use Dilatation, Pathologic Fluorescein Angiography Humans Indocyanine Green / diagnostic use Macula Lutea Macular Degeneration / physiopathology* Middle Aged Photography Prospective Studies Veins / pathology |
| Chemical | |
Reg. No./Substance:
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0/Coloring Agents; 3599-32-4/Indocyanine Green |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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