| Decreased apolipoprotein A5 is implicated in insulin resistance-related hypertriglyceridemia in obesity. | |
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MedLine Citation:
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PMID: 20047745 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypertriglyceridemia is associated insulin resistance in obese people. Recently identified apolipoprotein A5 (apoA5) is involved in triglyceride (TG) metabolism. This study was to investigate the role of apoA5 in insulin resistance-related hypertriglyceridemia in obesity. 682 participants including 340 non-obese individuals and 342 obese individuals were recruited in this study. Plasma apoA5 levels were measured. The insulin resistance in participants was assessed by homeostasis model assessment of insulin resistance (HOMA-IR). An insulin resistant and hypertriglyceridemic rat model was established by high-fructose diet with obese Zucker rats as positive controls. Besides, two insulin resistant models in vitro were induced by insulin and tumor necrosis factor-alpha (TNFalpha) in HepG2 cells. Obese participants had lower plasma apoA5 levels. Plasma apoA5 levels were inversely correlated with TG, body mass index and HOMA-IR in humans. Furthermore, hepatic and plasma apoA5 reduced in fructose-fed rats whereas no significant changes of apoA5 were observed in obese Zucker rats. In addition, treatment of HepG2 cells with insulin and TNFalpha decreased apoA5 expression and increased TG content. Thus, decreased apolipoprotein A5 is implicated in insulin resistance-related hypertriglyceridemia in obesity. |
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Authors:
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Xian-sheng Huang; Shui-Ping Zhao; Min Hu; Lin Bai; Qian Zhang; Wang Zhao |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-12-11 |
Journal Detail:
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Title: Atherosclerosis Volume: 210 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-31 Completed Date: 2010-12-06 Revised Date: 2011-05-06 |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 563-8 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Cardiology, The Second Xiang Ya Hospital, Central South University, No. 139, Renmin Zhonglu, Changsha, Hunan, 410011, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Animals Apolipoproteins / blood* Apolipoproteins A / blood* Female Glucose Clamp Technique Humans Hypertriglyceridemia / complications* Insulin / metabolism Insulin Resistance* Male Middle Aged Obesity / complications* Rats Rats, Zucker Tumor Necrosis Factor-alpha / metabolism |
| Chemical | |
Reg. No./Substance:
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0/APOA5 protein, human; 0/Apoa5 protein, rat; 0/Apolipoproteins; 0/Apolipoproteins A; 0/Tumor Necrosis Factor-alpha; 11061-68-0/Insulin |
| Comments/Corrections | |
Comment In:
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Atherosclerosis. 2010 Oct;212(2):386-7
[PMID:
20638662
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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