| Decreased antioxidase activities and oxidative stress in the spleen of chickens fed on high-fluorine diets. | |
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MedLine Citation:
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PMID: 21071555 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Three hundred one-day-old avian broilers were divided into four equal groups of 75 animals that were fed for 42 days as follows: a control diet containing 23 mg fluorine (F)/kg and three high F diets containing 400, 800, and 1200 mg F/kg, respectively, for high F groups I, II, and III. The superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities were greatly decreased, while the malondialdehyde (MDA) contents were markedly increased in high F groups II and III. At the same time, mitochondrial injury and expanded endocytoplasmic reticulum were obviously observed in high F groups II and III, and the fluoride contents both in spleen and serum were significantly increased in the three high F groups when compared with those of control group. The results showed that excess dietary F in the range of 800-1200 mg/kg caused obvious oxidative stress, which provided a possible pathway for the apoptosis of splenocytes in chickens. |
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Authors:
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Tao Chen; Hengmin Cui; Yun Cui; Caimin Bai; Tao Gong |
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Publication Detail:
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Type: Journal Article Date: 2010-11-11 |
Journal Detail:
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Title: Human & experimental toxicology Volume: 30 ISSN: 1477-0903 ISO Abbreviation: Hum Exp Toxicol Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-09-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9004560 Medline TA: Hum Exp Toxicol Country: England |
Other Details:
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Languages: eng Pagination: 1282-6 Citation Subset: IM |
Affiliation:
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1Department of Veterinary Medicine, Sichuan Agricultural University, Ya'an, Sichuan, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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