Document Detail

Decreased amino acid uptake by erythrocytes during postoperative sepsis.
MedLine Citation:
PMID:  7882523     Owner:  NLM     Status:  MEDLINE    
We describe a patient with postoperative sepsis associated with reduced ability to transport amino acids into erythrocytes. Administration of amino acid infusion showed no effect on plasma or red blood cell concentrations of the amino acids during the sepsis period. However, when the site of sepsis was removed, patient recovery was associated with marked increases of all amino acids, particularly in the red blood cells. The case illustrates the potential of red blood cells as a marker of amino acid utilization and demonstrates the association of sepsis with effects on cellular uptake.
N B Roberts; R Wilkes
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical chemistry     Volume:  41     ISSN:  0009-9147     ISO Abbreviation:  Clin. Chem.     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-04-13     Completed Date:  1995-04-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9421549     Medline TA:  Clin Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  462-4     Citation Subset:  IM    
Department of Clinical Chemistry, Royal Liverpool University Hospital, UK.
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MeSH Terms
Amino Acids / administration & dosage,  blood*
Erythrocytes / metabolism*
Glutamine / blood
Gram-Negative Bacterial Infections / blood*
Parenteral Nutrition, Total
Postoperative Complications*
Sepsis / blood*
Reg. No./Substance:
0/Amino Acids; 56-85-9/Glutamine

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