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Decreased Urethral Mucosal Damage and Delayed Bacterial Colonization During Short-Term Urethral Catheterization Using a Novel Trefoil Urethral Catheter Profile in Rabbits.
MedLine Citation:
PMID:  21855927     Owner:  NLM     Status:  Publisher    
PURPOSE: We evaluated the efficacy of a novel catheter with a trefoil profile to decrease urothelial irritation and delay catheter associated urinary tract infections by comparing it with a conventional catheter in the rabbit model. MATERIALS AND METHODS: A novel catheter was made of medical silicone with a trefoil profile design. A total of 66 male New Zealand White rabbits were anesthetized and equally randomized into a control or a novel trefoil profile catheter group. Of the animals 10 per group were sacrificed at days 2, 4 and 8 of catheterization, respectively. Urine samples were cultured and urethral tissues were histopathologically evaluated. The remaining 6 rabbits were selected for urethral endoscopic assessment at day 10. RESULTS: After 4 days of catheterization the novel trefoil catheter profile decreased the rate of bacteriuria, defined as less than 100 cfu/ml, in 3 rabbits with a novel catheter vs that in 8 with a control catheter (p <0.05). Histopathological assessment revealed minor differences in staining in the short term. Endoscopic assessment showed more obvious mucosal inflammatory changes in 2 of the 3 controls than in the 3 rabbits with a novel catheter. CONCLUSIONS: Results demonstrate that the novel catheter harbors a property of decreasing urothelial irritation and delaying catheter associated urinary tract infection. This advantage over conventional catheters makes it a potential alternative for short-term catheterization. Clinical trials are forthcoming.
Yinghao Sun; Qinsong Zeng; Zhensheng Zhang; Chuanliang Xu; Yang Wang; Jiangnan He
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-18
Journal Detail:
Title:  The Journal of urology     Volume:  -     ISSN:  1527-3792     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.
Department of Urology, Changhai Hospital, Shanghai, People's Republic of China.
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