Document Detail

Decreased serine207 phosphorylation of troponin T as a biomarker for left ventricular remodelling after myocardial infarction.
MedLine Citation:
PMID:  20418543     Owner:  NLM     Status:  In-Process    
AIMS: Chronic heart failure following myocardial infarction (MI) is characterized by progressive left ventricular remodelling (LVR). Despite significant improvements in MI management, LVR remains a frequent complication. Although several risk factors have been identified, such as infarct size, LVR is difficult to predict in clinical practice.
METHODS AND RESULTS: Using a rat model of MI and phosphoproteomic technology, we discovered that remodelling is associated with decreased levels of myocardial and plasma serine(208)-phosphorylated troponin T (TnT). To confirm the association in human plasma, we developed new specific polyclonal antibodies against human/rat serine(207/208)-phosphorylated TnT and tested plasma obtained in the first week after MI from patients with low, intermediate, and high remodelling a year later. We observed a significant decrease of serine(207)-phosphorylated TnT and of the serine(207)-phosphorylated TnT/total TnT ratio in those with intermediate or high LVR. These differences remained statistically significant when adjusted for other determinants of LVR. In contrast, baseline B-type natriuretic peptide levels were not associated with LVR.
CONCLUSION: The level of circulating phosphorylated TnT could be a new biomarker of LVR.
Emilie Dubois; Vincent Richard; Paul Mulder; Nicolas Lamblin; Hervé Drobecq; Jean-Paul Henry; Philippe Amouyel; Christian Thuillez; Christophe Bauters; Florence Pinet
Related Documents :
15120803 - Angina pectoris prior to myocardial infarction protects against subsequent left ventric...
19535683 - Targeting vegf-encapsulated immunoliposomes to mi heart improves vascularity and cardia...
11306523 - Elevated levels of oxidized low density lipoprotein show a positive relationship with t...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-04-25
Journal Detail:
Title:  European heart journal     Volume:  32     ISSN:  1522-9645     ISO Abbreviation:  Eur. Heart J.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  England    
Other Details:
Languages:  eng     Pagination:  115-23     Citation Subset:  IM    
INSERM U744, Lille, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Disruption of lysosome function promotes tumor growth and metastasis in drosophila.
Next Document:  Estimating the population impact of screening strategies for identifying and treating people at high...