Document Detail

Decreased R-R variance in panic disorder patients.
MedLine Citation:
PMID:  2378249     Owner:  NLM     Status:  MEDLINE    
To investigate autonomic function in panic disorder patients (n = 30), we compared postural changes in heart rate and the R-R interval variance in patients and normal controls (n = 20). There was no significant difference in the immediate changes in heart rate upon standing between the groups. R-R variance was significantly decreased during resting supine condition in patients as indicated by the corrected standard deviation of the R-R intervals. The standing R-R variance was significantly lower than that of normal controls as indicated by the corrected standard deviations, the corrected mean consecutive difference and the corrected standard deviation of the mean consecutive difference of the R-R intervals, suggesting an increase in vagal withdrawal in patients, especially upon standing. If this finding is specific to panic disorder patients, it may be a useful peripheral marker for this condition.
V K Yeragani; R Balon; R Pohl; C Ramesh; D Glitz; P Weinberg; B Merlos
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Acta psychiatrica Scandinavica     Volume:  81     ISSN:  0001-690X     ISO Abbreviation:  Acta Psychiatr Scand     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-09-04     Completed Date:  1990-09-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370364     Medline TA:  Acta Psychiatr Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  554-9     Citation Subset:  IM    
Adult Outpatient Department, Lafayette Clinic, Detroit, MI 48207.
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MeSH Terms
Anxiety Disorders / diagnosis,  physiopathology*
Arousal / physiology*
Cholinergic Fibers / physiology
Fear / physiology*
Heart Rate / physiology
Middle Aged
Panic / physiology*
Posture / physiology
Respiration / physiology
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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