Document Detail


Decreased Phosphorylation and Increased Methionine Oxidation of α-Synuclein in the Methionine Sulfoxide Reductase A Knockout Mouse.
MedLine Citation:
PMID:  22332004     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Previously, we have showed that overexpression of methionine-oxidized α-synuclein in methionine sulfoxide reductase A (MsrA) null mutant yeast cells inhibits α-synuclein phosphorylation and increases protein fibrillation. The current studies show that ablation of mouse MsrA gene caused enhanced methionine oxidation of α-synuclein while reducing its own phophorylation levels, especially in the hydrophobic cell-extracted fraction. These data provide supportive evidence that a compromised MsrA function in mammalian brain may cause enhanced pathologies associated with altered α-synuclein oxidation and phosphorylation levels.
Authors:
Derek B Oien; Gonzalo A Carrasco; Jackob Moskovitz
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Publication Detail:
Type:  Journal Article     Date:  2011-01-12
Journal Detail:
Title:  Journal of amino acids     Volume:  2011     ISSN:  2090-0112     ISO Abbreviation:  J Amino Acids     Publication Date:  2011  
Date Detail:
Created Date:  2012-02-14     Completed Date:  2012-08-23     Revised Date:  2013-03-14    
Medline Journal Info:
Nlm Unique ID:  101568074     Medline TA:  J Amino Acids     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  721094     Citation Subset:  -    
Affiliation:
Department of Pharmacology and Toxicology, School of Pharmacy, The University of Kansas, Lawrence, KS 66045, USA.
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Erratum In:
J Amino Acids. 2012;2012:415713

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