| Decreased Neuromuscular Function in Crohn's Disease Patients Is Not Associated with Low Serum Vitamin D Levels. | |
| | |
MedLine Citation:
|
PMID: 22949179 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: Neuromuscular fatigue is a common complaint in Crohn's disease (CD) patients. A correlation between serum vitamin D concentrations and neuromuscular function has been found in the elderly or non-ambulant populations. AIMS: The aim of this study was to determine whether CD patients exhibit impaired neuromuscular function and if so, is there a link between vitamin D and neuromuscular function. METHODS: Crohn's disease patients (n = 19) with at least one prior small bowel resection and matched controls (n = 19) underwent muscle strength and endurance testing, vitamin D, and nerve function analysis. RESULTS: Knee extension and flexion peak torque (Nm/kg) were greater in the control group than in the CD patients (P = 0.04 and 0.014, respectively. A significant difference was found between fatigue rates of the rectus femoris (P = 0.015) between CD patients and controls, but no difference was found in serum vitamin D levels between groups (P = 0.317). Knee extension and flexion torque measurements, with age as a covariate, were compared with high and low vitamin D levels. Those subjects with high serum vitamin D levels had a significantly greater extension peak torque (P = 0.045) and extension average torque (Nm/kg) (P = 0.014) than those with low levels. CONCLUSION: Crohn's disease patients with sufficient vitamin D levels experienced a 43 % greater extension peak torque. Although vitamin D deficiency has been associated with neuromuscular dysfunction, there were no differences in serum vitamin D levels between the CD and healthy controls to explain the decreased muscle strength. |
| | |
Authors:
|
Amanda J Salacinski; Miguel D Regueiro; Craig E Broeder; Jean L McCrory |
Related Documents
:
|
23208339 - Severe pulmonary hypertension associated with emphysema: a new phenotype? 23446309 - Volatile breath biomarkers for patient monitoring during haemodialysis. 23190179 - Lumbar drains may reduce the need for permanent csf diversion in spontaneous subarachno... 23699359 - Increased levels of il-8 in balf from patients with pulmonary alveolar proteinosis. 23534529 - Effect of nonsurgical periodontal treatment on c-reactive protein levels in maintenance... 23312969 - Surgical and neurologic outcomes after robotic thymectomy in 100 consecutive patients w... 1382719 - Genomic hypomethylation in human chronic lymphocytic leukemia. 3489979 - A preliminary study of low-dose splenic irradiation for the treatment of chronic lympho... 2007779 - Nodular regenerative hyperplasia of the liver: an important cause of portal hypertensio... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-9-5 |
Journal Detail:
|
Title: Digestive diseases and sciences Volume: - ISSN: 1573-2568 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 2012 Sep |
Date Detail:
|
Created Date: 2012-9-5 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Kinesiology and Physical Education, Northern Illinois University, 204 Anderson Hall, DeKalb, IL, 60115, USA, asalacinski@niu.edu. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Successful use of plasmapheresis for granulomatosis with polyangiitis presenting as diffuse alveolar...
Next Document: Empathy for pain: The effects of prior experience and sex.