Document Detail


Decreased liver fatty acid delta-6 and delta-5 desaturase activity in obese patients.
MedLine Citation:
PMID:  19875987     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Steatosis in obese nonalcoholic fatty liver disease (NAFLD) patients is a clinicopathological condition associated with depletion of n-3 polyunsaturated fatty acids (PUFA), a feature that may be related to PUFA desaturation. Liver Delta-6 and Delta-5 desaturase (Delta-6D and Delta-5D) activities, homeostasis model assessment of insulin resistance (HOMA(IR)), and ferric reducing ability of plasma (FRAP) were evaluated in 13 obese patients who underwent subtotal gastrectomy with gastro-jejunal anastomosis in Roux-en-Y and 15 nonobese patients who underwent laparoscopic cholecystectomy (controls). Liver Delta-6D and Delta-5D activities in obese patients were 87% and 66% lower than controls (P < 0.001), respectively, with a 62% diminution in the Delta-6D/Delta-5D activity ratio (P < 0.02). Delta-6D inversely correlated with both HOMA(IR) (r = -0.70, P < 0.0001) and oxidative stress assessed as the reciprocal value of FRAP (r = -0.40, P < 0.05). Delta-5D negatively correlated with HOMA(IR) (r = -0.48, P < 0.01) but not with FRAP(-1) (r = -0.13, not significant). In conclusion, liver PUFA desaturation is diminished in obese NAFLD patients, in association with underlying insulin resistance and oxidative stress, which may play a role in altering lipid metabolism favoring fatty infiltration.
Authors:
Julia Araya; Ramón Rodrigo; Paulina Pettinelli; A Verónica Araya; Jaime Poniachik; Luis A Videla
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-10-29
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  18     ISSN:  1930-739X     ISO Abbreviation:  Obesity (Silver Spring)     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-28     Completed Date:  2010-09-29     Revised Date:  2012-08-13    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1460-3     Citation Subset:  IM    
Affiliation:
Department of Nutrition, Faculty of Medicine, University of Chile, Santiago, Chile.
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MeSH Terms
Descriptor/Qualifier:
Adult
Cholecystectomy, Laparoscopic
Enzyme Activation / physiology
Fatty Acid Desaturases / metabolism*
Fatty Acids, Unsaturated / metabolism
Fatty Liver / enzymology*,  surgery
Female
Gastric Bypass
Homeostasis / physiology
Humans
Insulin Resistance / physiology
Linoleoyl-CoA Desaturase / metabolism*
Lipid Metabolism / physiology
Liver / enzymology*
Male
Obesity / enzymology*,  surgery
Oxidative Stress / physiology
Chemical
Reg. No./Substance:
0/Fatty Acids, Unsaturated; EC 1.14.19.-/Fatty Acid Desaturases; EC 1.14.19.3/Linoleoyl-CoA Desaturase; EC 1.14.99.-/delta-5 fatty acid desaturase

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