Document Detail


Decreased H2O2 in exhaled breath condensate during pregnancy--feasible effect of 17beta-estradiol.
MedLine Citation:
PMID:  18585485     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Since pregnancy is known to favor systemic generation of reactive oxygen species, this study was designed to assess the levels of exhaled hydrogen peroxide (eH2O2), serum progesterone (PG), 17beta-estradiol (E2) and systemic oxidative parameters in 20 pregnant women between 15th and 28th gestation week and 23 healthy, eumenorrheic women. Exhaled breath condensate H2O2 was assessed fluorometrically with homovanillic acid. Exhaled H2O2 levels were lowered in pregnancy (median Me 0.13 microM) compared with follicular (Me 0.29 microM) or luteal phase (Me 0.26 microM; p<0.05 vs. both). The follicular H2O2 tended to exceed luteal phase. Whole blood chemiluminescence was increased approximately ten fold in pregnancy. E2 markedly decreased chemiluminescence of isolated polymorphonuclear leukocytes. In vitro ferric reducing ability of plasma and 2,2-diphenyl-1-picryl-hydrazyl scavenging assay were not affected by E2 or PG. Decreased exhaled H2O2 during pregnancy, despite of the increased oxidative capacity of peripheral phagocytes, might be ascribed to the magnitude of increased 17beta-estradiol levels.
Authors:
R Stolarek; U Szkudlarek; M Luczynska; M Kasielski; W Ciesla; A Lewinski; D Nowak
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-06-08
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  162     ISSN:  1569-9048     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-22     Completed Date:  2008-10-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  152-9     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular Physiology, Mazowiecka Street 6/8, 92-215 Lodz, Poland. rastolarek@zdn.umed.lodz.pl
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MeSH Terms
Descriptor/Qualifier:
Adult
Breath Tests
Case-Control Studies
Estradiol / metabolism*
Exhalation / physiology*
Female
Humans
Hydrogen Peroxide / analysis,  metabolism*
Menstrual Cycle / metabolism*
Phagocytes / metabolism
Pregnancy / metabolism*
Reactive Oxygen Species / metabolism
Spirometry
Chemical
Reg. No./Substance:
0/Reactive Oxygen Species; 50-28-2/Estradiol; 7722-84-1/Hydrogen Peroxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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