| Decreased FKBP12.6 expression and enhanced endothelin receptor signaling associated with arrhymogenesis in myocardial infarction rats. | |
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MedLine Citation:
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PMID: 18570278 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An increased propensity towards cardiac arrhythmias and aggravated heart function is observed in myocardial infarction (MI), the development of which is associated with the calcium handling system in the myocardium. It was hypothesized that the abnormal changes in the MI model may be a consequence of the abnormal expression and function of the RyR2-FKBP12.6 channel complex and that these abnormalities may be related to an over-activated endothelin (ET) system. Salvianolic acid B is expected to suppress life-threatening arrhythmias and to restore the abnormality of the RyR2-FKBP12.6 complex in rats. MI was produced by ligating the coronary artery for 4 weeks. Salvianolic acid B (100 mg/kg/day, p.o. for 4 weeks) was administered to rats 0.5 h before surgery. Measurements of cardiac arrhythmias, cardiac function, calcium transient, cardiac calcium release channel handling proteins and the endothelin system were conducted. The aggravated arrhythmia and compromised cardiac function in MI rats was accompanied by elevated diastolic Ca(2+) levels in the cytosol and a significant down-regulation of expression of RyR2-FKBP12.6. These were closely linked with an over-activated ET pathway in the myocardium. After a 4-week treatment with salvianolic acid B, all abnormalities were reversed significantly. Salvianolic acid B was capable of normalizing FKBP12.6 expression levels and decreasing the propensity towards arrhythmias by attenuating the up-regulated ET pathway. |
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Authors:
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Haibo He; Mengqiong Shi; Xiaowei Zeng; Xianzhe Yang; Jun Yang; Limao Wu; Lianda Li |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Retracted Publication |
Journal Detail:
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Title: Phytotherapy research : PTR Volume: 22 ISSN: 1099-1573 ISO Abbreviation: Phytother Res Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-05 Completed Date: 2008-10-02 Revised Date: 2009-01-28 |
Medline Journal Info:
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Nlm Unique ID: 8904486 Medline TA: Phytother Res Country: England |
Other Details:
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Languages: eng Pagination: 1115-24 Citation Subset: IM |
Affiliation:
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Institute of Chinese Herb Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058, PRC. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arrhythmias, Cardiac / drug therapy, metabolism*, physiopathology Benzofurans / therapeutic use* Calcium / metabolism Disease Models, Animal Drugs, Chinese Herbal / therapeutic use* Gene Expression / drug effects Hemodynamics / drug effects Male Myocardial Infarction / drug therapy, metabolism*, physiopathology Myocardial Reperfusion Injury / drug therapy, metabolism, physiopathology Myocytes, Cardiac / drug effects, metabolism Rats Rats, Sprague-Dawley Receptors, Endothelin / metabolism* Ryanodine Receptor Calcium Release Channel / genetics, metabolism Signal Transduction Tacrolimus Binding Proteins / genetics, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Benzofurans; 0/Drugs, Chinese Herbal; 0/Receptors, Endothelin; 0/Ryanodine Receptor Calcium Release Channel; 115939-25-8/salvianolic acid B; 7440-70-2/Calcium; EC 5.2.1.-/Tacrolimus Binding Proteins; EC 5.2.1.-/tacrolimus binding protein 1B |
| Comments/Corrections | |
Retraction In:
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Coats A, Williamson EM. Phytother Res. 2008 Dec;22(12):1698
[PMID:
19067374
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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