| Decreased Endothelial Progenitor Cells and Increased Serum Glycated Albumin Are Independently Correlated With Plaque-Forming Carotid Artery Atherosclerosis in Type 2 Diabetes Patients Without Documented Ischemic Disease. | |
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MedLine Citation:
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PMID: 22664650 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: The aim of the present study was to investigate the serum levels of endothelial progenitor cells (EPCs) in type 2 diabetic patients without documented ischemic disease and the association between EPCs and atherosclerotic plaque formation in the carotid artery. Methods and Results: A clinic-based, prospective study of type 2 diabetic patients was conducted. A total of 73 subjects were enrolled in this study after cardiac magnetic resonance imaging and ankle-brachial index measurements to exclude patients with ischemic disease. Plaque formation in the carotid artery was measured on ultrasonography. Circulating EPCs (CD34<sup>+</sup>/CD133<sup>+</sup>/CD309<sup>+</sup> cells) were counted on flow cytometry. Compared to subjects without carotid artery plaques, patients with plaques were significantly older (P=0.006) and had decreased EPC count (P=0.027). Serum glycated albumin (GA) level and the GA/glycated hemoglobin ratio tended to decrease in patients with plaques (P=0.091 and 0.067, respectively). Other cardiovascular disease risk factors were not significantly different between the 2 groups. On binary logistic regression analysis old age, low EPC count, and high serum GA level were independently correlated with carotid artery plaque formation. Conclusions: EPC count and serum GA level appear to be a protective and an aggravating factor for endothelial damage, respectively, and therefore, a reduced EPC count or an increased GA level results in atherosclerotic plaque formation in type 2 diabetic patients. |
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Authors:
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Jae Hoon Moon; Min Kyung Chae; Kwang Joon Kim; Hyun Min Kim; Bong Soo Cha; Hyun Chul Lee; Young Jin Kim; Byung-Wan Lee |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-6-01 |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: - ISSN: 1347-4820 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-6-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Internal Medicine, Seoul National University Bundang Hospital. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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