| Decreased cortical somatosensory finger representation in X-linked recessive bulbospinal neuronopathy (Kennedy disease): a magnetoencephalographic study. | |
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MedLine Citation:
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PMID: 19187481 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Kennedy disease (KD) clinically presents as progressive lower motor neuron disease with minimal or no sensory impairment. However, electrophysiological studies found abnormal somatosensory-evoked potentials even in absence of clinical deficits. Little is known about possible influences of this sensory neuropathy on the central somatosensory processing. METHODS: In this study, the cortical topography of index finger representation was studied in 7 patients with genetically proven KD compared to healthy control subjects by means of magnetoencephalography using an established stimulation paradigm. Data analysis was carried out with synthetic aperture magnetometry (SAM). Additionally, the latency and source amplitude of the earliest cortical somatosensory-evoked field (SEF) component were determined based on traditional single dipole source analysis. RESULTS: In KD patients the latency of the SEF was prolonged (48.6 vs. 37.4 ms, P < .005). There was no significant difference in dipole source amplitude, but stimulus-related SAM activation of the contralateral sensorimotor cortex (pseudo-t-values -.107 vs. -.199, P < .05), including maximum activity (53.5%), was reduced. CONCLUSIONS: These results implicate that even subclinical sensory neuropathy leads to possible functional reorganization of the sensorimotor cortex in KD patients and reinforces the view that in KD the somatosensory system is extensively involved. |
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Authors:
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Sonja Suntrup; Inga Kristina Teismann; Olaf Steinstraeter; Erich Bernd Ringelstein; Christo Pantev; Rainer Dziewas |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-01-29 |
Journal Detail:
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Title: Journal of neuroimaging : official journal of the American Society of Neuroimaging Volume: 20 ISSN: 1552-6569 ISO Abbreviation: J Neuroimaging Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-05-24 Completed Date: 2010-09-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9102705 Medline TA: J Neuroimaging Country: United States |
Other Details:
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Languages: eng Pagination: 16-21 Citation Subset: IM |
Affiliation:
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Department of Neurology, University of Muenster, Muenster, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Brain / pathology, physiopathology* Bulbo-Spinal Atrophy, X-Linked / pathology, physiopathology* Case-Control Studies Evoked Potentials, Somatosensory Fingers / physiology* Functional Laterality Humans Magnetic Resonance Imaging Magnetoencephalography / methods Male Middle Aged Physical Stimulation Signal Processing, Computer-Assisted Somatosensory Cortex / pathology, physiopathology* Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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