| Decreased calcitriol requirement during pregnancy and lactation with a window of increased requirement immediately post partum. | |
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MedLine Citation:
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PMID: 20061285 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To describe the changes in calcium and calcitriol requirements during pregnancy and lactation in a patient with hypoparathyroidism due to autosomal dominant hypocalcemia. METHODS: We summarize the clinical presentation and treatment of the patient and review the pertinent literature. RESULTS: Calcitriol requirements disappeared during pregnancy in a 34-year-old woman with autosomal dominant hypoparathyroidism secondary to an activating mutation in the calcium-sensing receptor gene. Within hours after delivery, her serum calcium concentration dropped to 4.7 mg/dL (albumin, 3.2 g/dL), and she required intravenous calcium and reinstitution of calcitriol. When lactation began a few days later, her calcitriol requirement again disappeared. As has occasionally been described in the literature, this patient with hypoparathyroidism required no calcitriol during late pregnancy and lactation to maintain a normal serum calcium level. CONCLUSIONS: To our knowledge, this is the first reported case documenting a period of time between pregnancy and lactation when calcitriol requirements reappeared, likely due to a parathyroid hormone-related protein "window" between delivery, when placental production of parathyroid hormone-related protein stops, and lactation, when mammary gland production begins. |
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Authors:
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Laura L Sweeney; Alan O Malabanan; Harold Rosen |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists Volume: 16 ISSN: 1934-2403 ISO Abbreviation: Endocr Pract Publication Date: 2010 May-Jun |
Date Detail:
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Created Date: 2010-06-16 Completed Date: 2010-09-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9607439 Medline TA: Endocr Pract Country: United States |
Other Details:
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Languages: eng Pagination: 459-62 Citation Subset: IM |
Affiliation:
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Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Calcitriol
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therapeutic use* Female Humans Hypoparathyroidism / drug therapy* Lactation / physiology* Postpartum Period* Pregnancy |
| Chemical | |
Reg. No./Substance:
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32222-06-3/Calcitriol |
| Comments/Corrections | |
Comment In:
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Endocr Pract. 2010 May-Jun;16(3):522-3
[PMID:
20551009
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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