Document Detail

Decreased C-reactive protein levels in Alzheimer disease.
MedLine Citation:
PMID:  19933496     Owner:  NLM     Status:  MEDLINE    
C-reactive protein (CRP) is an acute-phase reactant that has been found to be associated with Alzheimer disease (AD) in histopathological and longitudinal studies; however, little data exist regarding serum CRP levels in patients with established AD. The current study evaluated CRP levels in 192 patients diagnosed with probable AD (mean age = 75.8 +/- 8.2 years; 50% female) as compared to 174 nondemented controls (mean age = 70.6 +/- 8.2 years; 63% female). Mean CRP levels were found to be significantly decreased in AD (2.9 microg/mL) versus controls (4.9 microg/mL; P = .003). In adjusted models, elevated CRP significantly predicted poorer (elevated) Clinical Dementia Rating Scale sum of boxes (CDR SB) scores in patients with AD. In controls, CRP was negatively associated with Mini-Mental State Examination (MMSE) scores and positively associated with CDR SB scores. These findings, together with previously published results, are consistent with the hypothesis that midlife elevations in CRP are associated with increased risk of AD development though elevated CRP levels are not useful for prediction in the immediate prodrome years before AD becomes clinically manifest. However, for a subgroup of patients with AD, elevated CRP continues to predict increased dementia severity suggestive of a possible proinflammatory endophenotype in AD.
Sid E O'Bryant; Stephen C Waring; Valerie Hobson; James R Hall; Carol B Moore; Teodoro Bottiglieri; Paul Massman; Ramon Diaz-Arrastia
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-11-20
Journal Detail:
Title:  Journal of geriatric psychiatry and neurology     Volume:  23     ISSN:  0891-9887     ISO Abbreviation:  J Geriatr Psychiatry Neurol     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-10     Completed Date:  2010-05-11     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  8805645     Medline TA:  J Geriatr Psychiatry Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  49-53     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Alzheimer Disease / blood*,  diagnosis
Biological Markers / blood
C-Reactive Protein / metabolism*
Dementia / blood*,  diagnosis
Linear Models
Mental Status Schedule
Middle Aged
Predictive Value of Tests
Psychiatric Status Rating Scales
Severity of Illness Index
Time Factors
Grant Support
Reg. No./Substance:
0/Biological Markers; 9007-41-4/C-Reactive Protein

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