Document Detail


Decreased C-reactive protein levels in Alzheimer disease.
MedLine Citation:
PMID:  19933496     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
C-reactive protein (CRP) is an acute-phase reactant that has been found to be associated with Alzheimer disease (AD) in histopathological and longitudinal studies; however, little data exist regarding serum CRP levels in patients with established AD. The current study evaluated CRP levels in 192 patients diagnosed with probable AD (mean age = 75.8 +/- 8.2 years; 50% female) as compared to 174 nondemented controls (mean age = 70.6 +/- 8.2 years; 63% female). Mean CRP levels were found to be significantly decreased in AD (2.9 microg/mL) versus controls (4.9 microg/mL; P = .003). In adjusted models, elevated CRP significantly predicted poorer (elevated) Clinical Dementia Rating Scale sum of boxes (CDR SB) scores in patients with AD. In controls, CRP was negatively associated with Mini-Mental State Examination (MMSE) scores and positively associated with CDR SB scores. These findings, together with previously published results, are consistent with the hypothesis that midlife elevations in CRP are associated with increased risk of AD development though elevated CRP levels are not useful for prediction in the immediate prodrome years before AD becomes clinically manifest. However, for a subgroup of patients with AD, elevated CRP continues to predict increased dementia severity suggestive of a possible proinflammatory endophenotype in AD.
Authors:
Sid E O'Bryant; Stephen C Waring; Valerie Hobson; James R Hall; Carol B Moore; Teodoro Bottiglieri; Paul Massman; Ramon Diaz-Arrastia
Related Documents :
12865376 - Cardiac troponin t and c-reactive protein for predicting prognosis, coronary atheroscle...
11112466 - Abdominal aortic aneurysm and aortic occlusive disease: a comparison of risk factors an...
20716656 - Use of highly sensitive c-reactive protein for followup of wegener's granulomatosis.
18157956 - Relation between plasma adiponectin, high-sensitivity c-reactive protein, and coronary ...
15987396 - Effect of ventilator-associated tracheobronchitis on outcome in patients without chroni...
9671366 - A prospective study of unplanned endotracheal extubation in intensive care unit patients.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-11-20
Journal Detail:
Title:  Journal of geriatric psychiatry and neurology     Volume:  23     ISSN:  0891-9887     ISO Abbreviation:  J Geriatr Psychiatry Neurol     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-10     Completed Date:  2010-05-11     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  8805645     Medline TA:  J Geriatr Psychiatry Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  49-53     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Alzheimer Disease / blood*,  diagnosis
Biological Markers / blood
C-Reactive Protein / metabolism*
Dementia / blood*,  diagnosis
Female
Humans
Immunoassay
Linear Models
Male
Mental Status Schedule
Middle Aged
Predictive Value of Tests
Psychiatric Status Rating Scales
Severity of Illness Index
Time Factors
Grant Support
ID/Acronym/Agency:
P30 AG012300/AG/NIA NIH HHS; P30 AG12300/AG/NIA NIH HHS; R01 AG17869/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 9007-41-4/C-Reactive Protein
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Regulation of SIV mac 239 basal long terminal repeat activity and viral replication in macrophages: ...
Next Document:  Regulation of Monocyte Chemotactic Protein-1 Expression in Human Endometrial Endothelial Cells by Se...