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Decreased [99mTc]Sestamibi uptake with dobutamine versus dipyridamole stress.
MedLine Citation:
PMID:  20016457     Owner:  NLM     Status:  MEDLINE    
AIM: Animal studies suggest an interference of dobutamine on [99mTc]sestamibi uptake. In this study dobutamine was compared to dipyridamole rest-stress [99mTc]sestamibi uptake ratio (UR). METHODS: Twenty-five patients with suspect coronary artery disease (CAD) underwent rest, dobutamine, and dipyridamole [99mTc]sestamibi SPECT at 24-h intervals and coronary angiography. UR was calculated separately for each coronary territory considering injected dose and acquisition delay. RESULTS: There were 38 CAD territories in 20 patients. On a patient basis, dipyridamole SPECT sensitivity was 85%, versus 70% for dobutamine. On a territory basis, sensitivity was 66% versus 42% (P<0.05), and specificity 92% versus 86%, respectively for dipyridamole versus dobutamine. In the 38 CAD territories, dipyridamole UR was -4.1+/-29.4%, and dobutamine UR was -13.1+/-19.9% (P<0.05). In the 37 no-CAD territories, UR was 34+/-23.6% for dipyridamole and -0.4+/-17.8% for dobutamine (P<0.0001). UR difference between CAD versus no-CAD territories was larger using dipyridamole (P<0.0001) than dobutamine (P<0.005). CONCLUSIONS: The UR comparison confirms that [99mTc]sestamibi uptake underestimates the blood flow heterogeneity induced by dobutamine more than that produced by dipyridamole.
R Sciagr?; O Zoccarato; G Bisi; A Pupi
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Publication Detail:
Type:  Journal Article     Date:  2009-11-30
Journal Detail:
Title:  The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutical Chemistry and Biology     Volume:  53     ISSN:  1824-4785     ISO Abbreviation:  Q J Nucl Med Mol Imaging     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-17     Completed Date:  2010-04-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101213861     Medline TA:  Q J Nucl Med Mol Imaging     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  671-7     Citation Subset:  IM    
Nuclear Medicine Unit, Department of Clinical Physiopathology, University of Florence, Italy.
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MeSH Terms
Cohort Studies
Coronary Angiography / methods
Coronary Artery Disease / drug therapy
Dipyridamole / pharmacokinetics*
Dobutamine / pharmacokinetics*
Middle Aged
Sensitivity and Specificity
Technetium Tc 99m Sestamibi / pharmacokinetics*
Time Factors
Tomography, Emission-Computed, Single-Photon / methods
Reg. No./Substance:
109581-73-9/Technetium Tc 99m Sestamibi; 34368-04-2/Dobutamine; 58-32-2/Dipyridamole

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