Document Detail


Decreased 123I-MIBG uptake and increased clearance in various cardiac diseases.
MedLine Citation:
PMID:  8047317     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
123I-metaiodobenzylguanidine (MIBG), a tracer for sympathetic neuron integrity and function, was applied to 155 patients with various types of cardiac disease. The methods for quantification of MIBG and washout were studied as well as normal ranges. Heart-to-mediastinum average count ratio (H/M) correlated well with total heart count divided by injected activity (r = 0.60, P < 0.0001 and r = 0.72, P < 0.0001 for early and delayed images, respectively). Although as a whole left ventricular ejection fraction (LVEF) positively correlated with H/M ratio, decreased H/M ratio could be associated with normal LVEF, which may indicate that the MIBG activity was an independent variable compared with cardiac contractility. High washout rate was seen in various cardiac diseases, such as dilated cardiomyopathy, hypertrophic cardiomyopathy, ischaemic heart disease, hypertension, hypothyroidism and arrhythmia. The increased washout seems to be nonspecific to disease type, but is a common feature of damaged or failing myocardium.
Authors:
K Nakajima; J Taki; N Tonami; K Hisada
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nuclear medicine communications     Volume:  15     ISSN:  0143-3636     ISO Abbreviation:  Nucl Med Commun     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-09-01     Completed Date:  1994-09-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8201017     Medline TA:  Nucl Med Commun     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  317-23     Citation Subset:  IM    
Affiliation:
Department of Nuclear Medicine, Kanazawa University Hospital, Japan.
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MeSH Terms
Descriptor/Qualifier:
3-Iodobenzylguanidine
Erythrocytes
Gated Blood-Pool Imaging
Heart Diseases / radionuclide imaging*
Humans
Iodine Radioisotopes / diagnostic use*
Iodobenzenes / diagnostic use*
Middle Aged
Radionuclide Angiography
Reference Values
Sodium Pertechnetate Tc 99m / diagnostic use
Stroke Volume / physiology
Sympatholytics / diagnostic use*
Ventricular Function, Left / physiology
Chemical
Reg. No./Substance:
0/Iodine Radioisotopes; 0/Iodobenzenes; 0/Sympatholytics; 23288-60-0/Sodium Pertechnetate Tc 99m; 77679-27-7/3-Iodobenzylguanidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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