| Decreased 123I-MIBG uptake and increased clearance in various cardiac diseases. | |
MedLine Citation:
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PMID: 8047317 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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123I-metaiodobenzylguanidine (MIBG), a tracer for sympathetic neuron integrity and function, was applied to 155 patients with various types of cardiac disease. The methods for quantification of MIBG and washout were studied as well as normal ranges. Heart-to-mediastinum average count ratio (H/M) correlated well with total heart count divided by injected activity (r = 0.60, P < 0.0001 and r = 0.72, P < 0.0001 for early and delayed images, respectively). Although as a whole left ventricular ejection fraction (LVEF) positively correlated with H/M ratio, decreased H/M ratio could be associated with normal LVEF, which may indicate that the MIBG activity was an independent variable compared with cardiac contractility. High washout rate was seen in various cardiac diseases, such as dilated cardiomyopathy, hypertrophic cardiomyopathy, ischaemic heart disease, hypertension, hypothyroidism and arrhythmia. The increased washout seems to be nonspecific to disease type, but is a common feature of damaged or failing myocardium. |
Authors:
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K Nakajima; J Taki; N Tonami; K Hisada |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nuclear medicine communications Volume: 15 ISSN: 0143-3636 ISO Abbreviation: Nucl Med Commun Publication Date: 1994 May |
Date Detail:
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Created Date: 1994-09-01 Completed Date: 1994-09-01 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8201017 Medline TA: Nucl Med Commun Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 317-23 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine, Kanazawa University Hospital, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3-Iodobenzylguanidine Erythrocytes Gated Blood-Pool Imaging Heart Diseases / radionuclide imaging* Humans Iodine Radioisotopes / diagnostic use* Iodobenzenes / diagnostic use* Middle Aged Radionuclide Angiography Reference Values Sodium Pertechnetate Tc 99m / diagnostic use Stroke Volume / physiology Sympatholytics / diagnostic use* Ventricular Function, Left / physiology |
| Chemical | |
Reg. No./Substance:
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0/Iodine Radioisotopes; 0/Iodobenzenes; 0/Sympatholytics; 23288-60-0/Sodium Pertechnetate Tc 99m; 77679-27-7/3-Iodobenzylguanidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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