Document Detail

Decrease and structural modifications of phosphatidylethanolamine plasmalogen in the brain with Alzheimer disease.
MedLine Citation:
PMID:  10411344     Owner:  NLM     Status:  MEDLINE    
Several lipid modifications, some of which were attributed to oxidative stress, have been reported in the brains of patients with Alzheimer disease (AD). To evaluate this possibility, all phospholipids and their ether subclasses from the frontal cortex, hippocampus, and the white matter of AD brain were analyzed by high performance liquid chromatography and gas chromatography. The total phospholipid in the frontal cortex and hippocampus decreased on a DNA basis by about 20% and this change was essentially explained by a selective decrease in phosphatidylethanolamine and phosphatidylcholine. The lower content of phosphatidylethanolamine was due to a specific decrease in the plasmalogen subclass. Phosphatidylethanolamine plasmalogen was also the only lipid exhibiting major structural modifications: a significant decrease in polyunsaturated fatty acids and oleic acid as well as a shift of the aldehyde pattern from 18:1 to 18:0. The only modification observed in the other phospholipids was a decrease in oleic acid in diacyl-phosphatidylethanolamine and diacyl-phosphatidylcholine. None of these changes were observed in the white matter. Both the vinyl ether bond of phosphatidylethanolamine plasmalogen and polyunsaturated fatty acids are major targets in oxidative stress; thus, these specific lipid modifications strongly support the involvement of free radicals in the pathogenesis of AD.
Z Guan; Y Wang; N J Cairns; P L Lantos; G Dallner; P J Sindelar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neuropathology and experimental neurology     Volume:  58     ISSN:  0022-3069     ISO Abbreviation:  J. Neuropathol. Exp. Neurol.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-07-27     Completed Date:  1999-07-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985192R     Medline TA:  J Neuropathol Exp Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  740-7     Citation Subset:  IM    
Department of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
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MeSH Terms
Aged, 80 and over
Aldehydes / analysis
Alzheimer Disease / metabolism*
Brain / metabolism*
DNA / metabolism
Fatty Acids / analysis
Middle Aged
Nerve Tissue Proteins / metabolism
Phosphatidylcholines / chemistry,  metabolism
Phosphatidylethanolamines / chemistry,  metabolism
Phospholipids / metabolism
Plasmalogens / chemistry*,  metabolism*
Reg. No./Substance:
0/Aldehydes; 0/Fatty Acids; 0/Nerve Tissue Proteins; 0/Phosphatidylcholines; 0/Phosphatidylethanolamines; 0/Phospholipids; 0/Plasmalogens; 0/phosphatidal ethanolamines; 9007-49-2/DNA

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