Document Detail


Decrease of serotonin and metabolite in the forebrain and facilitation of lordosis by dorsal raphe nucleus lesions in male rats.
MedLine Citation:
PMID:  12507276     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In castrated male rats, a radiofrequency lesion was made in the dorsal raphe nucleus (DRL) and lordosis behavior was observed following treatment with estrogen. After the behavioral test, brains were removed and the contents of 5-HT and 5-HIAA in the forebrain were measured by high pressure liquid chromatography (HPLC). In the results, only 2 of 16 control males without brain surgery showed lordosis, and the mean lordosis quotient (LQ) was extremely low when compared to that in control females. In contrast, all male rats with DRL displayed lordosis and the mean LQ was higher than that of control males without brain surgery but lower than that in control females (P < 0.001). In the DRL males, 5-HT and 5-HIAA contents in the septum (SPT), the preoptic area (POA), the ventromedial hypothalamus (VMH) and the striatum (STM) were lower than those in control male and female groups (P < 0.001). These results suggest that the dorsal raphe nucleus prevents male rats from showing lordosis by serotonergic influence in the forebrain. In addition, HPLC results showed that levels of the 5-HT in the SPT, the POA and the VMH in the female group were higher than those in the control male group (P < 0.05). In female rats, the POA (P < 0.01) and the VMH (P < 0.05) contained larger 5-HT than those in the SPT and the STM, but there were no difference of 5-HT contents in the male rat.
Authors:
Masaki Kakeyama; Asami Umino; Toru Nishikawa; Korehito Yamanouchi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Endocrine journal     Volume:  49     ISSN:  0918-8959     ISO Abbreviation:  Endocr. J.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-12-31     Completed Date:  2003-05-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9313485     Medline TA:  Endocr J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  573-9     Citation Subset:  IM    
Affiliation:
Neuroendocrinology, Department of Basic Human Sciences, School of Human Sciences, Waseda University, Tokorozawa, Saitama 359-1192, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromatography, High Pressure Liquid
Corpus Striatum / chemistry
Female
Hydroxyindoleacetic Acid / analysis*
Hypothalamus, Middle / chemistry
Male
Orchiectomy
Ovariectomy
Posture*
Preoptic Area / chemistry
Prosencephalon / chemistry*
Raphe Nuclei / physiology*,  surgery
Rats
Rats, Wistar
Septum Pellucidum / chemistry
Serotonin / analysis*
Sexual Behavior, Animal / physiology*
Chemical
Reg. No./Substance:
50-67-9/Serotonin; 54-16-0/Hydroxyindoleacetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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