Document Detail

Decrease of rapid-eye-movement sleep in the light by intraventricular application of a VIP-antagonist in the rat.
MedLine Citation:
PMID:  3208098     Owner:  NLM     Status:  MEDLINE    
Vasoactive intestinal polypeptide (VIP) has been shown to increase the amount of time spent in rapid-eye-movement (REM) sleep both in cats and in rats. In the present study we examined the effect of a newly available competitive VIP-antagonist ([4Cl-D-Phe6-Leu17]-VIP) on sleep-wake patterns in male rats during both the light and the dark phase of 24 h. Continuous intracerebroventricular application of this VIP-antagonist reduced by 44% the amount of time spent in REM sleep during the light period. It is concluded that VIP may play a role in the generation and maintenance of REM sleep.
M Mirmiran; J Kruisbrink; N P Bos; D Van der Werf; G J Boer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain research     Volume:  458     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1989-02-22     Completed Date:  1989-02-22     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  192-4     Citation Subset:  IM    
Netherlands Institute for Brain Research, Amsterdam.
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MeSH Terms
Cerebral Ventricles / drug effects,  physiology*
Injections, Intraventricular
Rats, Inbred Strains
Reference Values
Sleep, REM / drug effects*
Vasoactive Intestinal Peptide / analogs & derivatives*,  antagonists & inhibitors*,  pharmacology
Reg. No./Substance:
102805-45-8/vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)-; 37221-79-7/Vasoactive Intestinal Peptide

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