| Decrease in oligodendrocyte carbonic anhydrase activity preceding myelin degeneration in cuprizone induced demyelination. | |
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MedLine Citation:
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PMID: 2440995 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Both immunohistochemical and biochemical evidence is presented to show for the first time that carbonic anhydrase II (CA II) activity falls in the brain of mice in cuprizone (bis(cyclohexanone)oxalyldihydrazone) induced demyelination well before demyelination develops. This fall began during the first week, whereas the first signs of myelin degeneration induced by cuprizone did not appear until 3 weeks and demyelination in the superior cerebellar peduncle in the mouse took 6-8 weeks to develop. The findings suggest that oligodendrocyte CA II activity is essential either for the survival of oligodendrocytes or for the maintenance of central myelin. |
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Authors:
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S Komoly; M D Jeyasingham; O E Pratt; P L Lantos |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the neurological sciences Volume: 79 ISSN: 0022-510X ISO Abbreviation: J. Neurol. Sci. Publication Date: 1987 Jun |
Date Detail:
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Created Date: 1987-08-28 Completed Date: 1987-08-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375403 Medline TA: J Neurol Sci Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 141-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / enzymology*, pathology Carbonic Anhydrases / metabolism* Cuprizone Demyelinating Diseases / chemically induced, enzymology*, metabolism, pathology Glial Fibrillary Acidic Protein / metabolism Male Mice Myelin Basic Proteins / metabolism Myelin Sheath / pathology* Nerve Degeneration Neuroglia / enzymology* Oligodendroglia / enzymology*, metabolism, pathology Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Glial Fibrillary Acidic Protein; 0/Myelin Basic Proteins; 370-81-0/Cuprizone; EC 4.2.1.1/Carbonic Anhydrases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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