Document Detail

Decrease in minimum alveolar concentration of sevoflurane during anaesthesia and arthroscopy.
MedLine Citation:
PMID:  12200951     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVE: Although the MACtetanus (minimum alveolar concentration that prevents movement in response to electrical tetanus stimulation in 50% of patients) of isoflurane decreases during anaesthesia and surgery, it is not known whether this occurs to the same extent with other inhalational anaesthetics. We determined the MACtetanus of sevoflurane before and after surgery. METHODS: Eleven patients who underwent arthroscopy of the shoulder underwent inhalational induction of anaesthesia with sevoflurane and tracheal intubation by succinylcholine. MACtetanus was determined in each patient by testing the response to a 10 s, 50 Hz, 80 mA transcutaneous tetanic electrical stimulus to the ulnar nerve at varying concentrations of sevoflurane. The end-tidal concentration of sevoflurane was kept constant for 15 min before each stimulus and the concentration of sevoflurane varied in increments of 0.1% until a sequence of three alternate responses (move, not move, move) or (not move, move, not move) was obtained. After arthroscopy of the shoulder, individual MACtetanus were measured as described above. RESULTS: The mean MACtetanus decreased from 2.22 +/- 0.29% before arthroscopy to 1.82 +/- 0.26% after arthroscopy (P < 0.01). CONCLUSIONS: It is concluded that the MACtetanus of sevoflurane decreases during anaesthesia and surgery.
H Higuchi; Y Adachi
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of anaesthesiology     Volume:  19     ISSN:  0265-0215     ISO Abbreviation:  Eur J Anaesthesiol     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-08-30     Completed Date:  2003-02-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8411711     Medline TA:  Eur J Anaesthesiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  600-3     Citation Subset:  IM    
Self Defense Force Hanshin Hospital, Department of Anaesthesia, 4-1-50 Kushiro, Kawanishi, Hyogo 666-0024, Japan.
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MeSH Terms
Anesthetics, Inhalation / administration & dosage,  pharmacokinetics*
Electric Stimulation
Intubation, Intratracheal
Methyl Ethers / administration & dosage,  pharmacokinetics*
Pulmonary Alveoli / metabolism*
Shoulder / surgery
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Methyl Ethers; 28523-86-6/sevoflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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