Document Detail

Decrease in mast cells in oral squamous cell carcinoma: possible failure in the migration of these cells.
MedLine Citation:
PMID:  16979374     Owner:  NLM     Status:  MEDLINE    
It is becoming accepted that multiple cell types in stromal microenvironment are involved in tumorigenesis. In this setting, mast cells (MC) display a diversity of roles that may contribute to the defense against tumors or tumor progression. Thus, the aim of this study was to evaluate density and migration of MCs in OSCC (oral squamous cell carcinoma) and pre-malignant oral hyperkeratosis (leukoplakia) as well as their relationship with clinical and microscopic parameters. The tryptase and c-kit expression was analyzed in 38 cases of OSCC, 26 cases of leukoplakia, and 12 cases of clinically healthy oral mucosa (control) by means of immunohistochemistry. The tryptase(+) cell numbers were decreased in OSCC (P=0.0003) and leukoplakia (P=0.03) compared with control. Similar numbers of tryptase(+) cells were observed in leukoplakia and OSCC (P=0.31). The density of c-kit(+) MCs was also significantly lower in OSCC and leukoplakia in relation to control resulting in a reduced c-kit(+)/tryptase(+) relationship in OSCC (19%) in comparison with leukoplakia (59%) and control (63%). No correlation was observed between MC populations with clinical and microscopic characteristics of OSCC. Our findings suggest that the decrease in MC numbers in pre-malignant and malignant oral lesions may be related to the migration failure of these cells, possibly reflecting an important modification in the microenvironment during tumor initiation and progression.
Helenisa Helena Oliveira-Neto; Angélica Ferreira Leite; Nádia Lago Costa; Rita Cássia Alencar; Vanessa Soares Lara; Tarcília Aparecida Silva; Claudio Rodrigues Leles; Francisco Elismauro Mendonça; Aline Carvalho Batista
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-09-18
Journal Detail:
Title:  Oral oncology     Volume:  43     ISSN:  1368-8375     ISO Abbreviation:  Oral Oncol.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-17     Completed Date:  2007-12-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9709118     Medline TA:  Oral Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  484-90     Citation Subset:  IM    
Dental School, Federal University of Goiás, Department of Stomatology (Oral Pathology), 74810-230 Goiânia, Goiás, Brazil.
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MeSH Terms
Carcinoma, Squamous Cell / immunology*,  mortality
Cell Movement / immunology*
Kaplan-Meiers Estimate
Leukoplakia, Oral / immunology
Mast Cells / immunology,  metabolism*
Middle Aged
Mouth Neoplasms / immunology*,  mortality
Stem Cell Factor / metabolism
Survival Analysis
Tryptases / metabolism
Reg. No./Substance:
0/Stem Cell Factor; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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