Document Detail

Decrease in lipogenesis and glucose oxidation of rat adipose tissue after chronic ethanol feeding.
MedLine Citation:
PMID:  3087366     Owner:  NLM     Status:  MEDLINE    
This investigation was performed to determine whether chronic ethanol feeding affects adipose tissue lipogenesis and glucose metabolism. Female Wistar rats were pair-fed nutritionally adequate liquid diets containing ethanol as 36% of energy or an isocaloric amount of carbohydrate for 3 weeks. Chronic ethanol feeding resulted in a depression of adipose tissue lipogenesis as assessed by labeled glucose incorporation into glyceride glycerol and glyceride fatty acids. Glucose oxidation was also impaired after chronic ethanol feeding. Such changes may contribute to the postprandial hypertriacyglyceridemia observed in alcoholics.
J S Wilson; M A Korsten; P W Colley; R C Pirola
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochemical pharmacology     Volume:  35     ISSN:  0006-2952     ISO Abbreviation:  Biochem. Pharmacol.     Publication Date:  1986 Jun 
Date Detail:
Created Date:  1986-07-16     Completed Date:  1986-07-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0101032     Medline TA:  Biochem Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2025-8     Citation Subset:  IM    
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MeSH Terms
Adipose Tissue / drug effects,  metabolism*
Carbon Dioxide / metabolism
Carbon Radioisotopes / diagnostic use
Deoxyglucose / metabolism
Ethanol / pharmacology*
Glucose / metabolism*
Lipids / biosynthesis*
Rats, Inbred Strains
Triglycerides / metabolism
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Lipids; 0/Triglycerides; 124-38-9/Carbon Dioxide; 154-17-6/Deoxyglucose; 50-99-7/Glucose; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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