| Decrease in interleukin-21 in children suffering with severe atopic dermatitis. | |
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MedLine Citation:
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PMID: 22122790 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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To cite this article: Lin S-C, Chuang Y-H, Yang Y-H, Chiang B-L. Decrease in interleukin-21 in children suffering with severe atopic dermatitis. Pediatr Allergy Immunol 2011: 22: 869-875. ABSTRACT: Background: Atopic dermatitis (AD) is a kind of eczema with an inflammatory, relapsing, non-contagious, and pruritic skin disorder. It is associated with the local infiltration of T helper type 2 (Th2) cells that secrete interleukin (IL)-4 and IL-5. IL-21 is a member of IL-2 family cytokine mainly expressed by activated CD4+ T lymphocytes. Until now, there is no clinical research in the expression of IL-21 in patients with AD. Methods: We analyzed serum levels of total immunoglobulin E (IgE), allergen-specific IgE, and cytokines IL-4, IL-5, IFN-γ, IL-17, and IL-21 in AD cases and controls. In addition, cytokine levels in the culture supernatants of peripheral blood mononuclear cells stimulated with anti-CD3 and anti-CD28 Abs, phytohemagglutin (PHA), or pokeweed mitogen (PWM) were measured. We also assessed clinical skin severity by Scoring of Atopic Dermatitis (SCORAD) index. Results: Our results showed that serum total IgE in the case group was significantly higher than that of control group (365.449 ± 52.945 and 39.243 ± 7.605 IU/ml, respectively). Logistic regression analysis system reveals serum levels of IL-21 and IFN-γ are significantly correlated. However, IL-21 and IL-4, IL-21 and IL-5, as well as IL-21 and IL-17 showed no correlation. Conclusion: A significantly decreased level of IL-21 was observed in children suffering with severe AD compared with controls, suggesting that IL-21 may play a role in AD. |
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Authors:
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Sheng-Chieh Lin; Ya-Hui Chuang; Yao-Hsu Yang; Bor-Luen Chiang |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology Volume: 22 ISSN: 1399-3038 ISO Abbreviation: Pediatr Allergy Immunol Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-11-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9106718 Medline TA: Pediatr Allergy Immunol Country: England |
Other Details:
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Languages: eng Pagination: 869-75 Citation Subset: IM |
Copyright Information:
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© 2011 John Wiley & Sons A/S. |
Affiliation:
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Department of Pediatrics, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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