Document Detail

Decrease in endothelium-dependent relaxation in the mesenteric arterial bed following vascular calcium overload produced by vitamin D3 and nicotine in rats.
MedLine Citation:
PMID:  1650877     Owner:  NLM     Status:  MEDLINE    
Treatment of young rats with vitamin D3 plus nicotine, which has been proposed as a model of cardiovascular calcium overload, produced an increase in the calcium content of the mesenteric arterial bed and lowered in vitro vasoconstrictor responses to norepinephrine and serotonin. Attenuation of the vasoconstriction induced by norepinephrine by the endothelium-dependent vasodilators, carbachol and histamine, was diminished, but the effects of sodium nitroprusside and papaverine were unchanged. The vitamin D3 plus nicotine model may be useful for the study of the involvement of calcium overload in vascular endothelial dysfunction.
D Henrion; J M Chillon; M Hoffman; C Capdeville-Atkinson; J Atkinson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Life sciences     Volume:  49     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1991  
Date Detail:
Created Date:  1991-09-12     Completed Date:  1991-09-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  575-86     Citation Subset:  IM    
Laboratoire de Pharmacologie Cardio-vasculaire, Faculté de Pharmacie, Nancy, France.
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MeSH Terms
Body Weight
Calcium / metabolism*
Carbachol / pharmacology
Cholecalciferol / pharmacology*
Endothelium / drug effects,  physiology*
Histamine / pharmacology
Muscle Relaxation* / drug effects
Muscle, Smooth, Vascular / physiology*
Nicotine / pharmacology*
Nitroprusside / pharmacology
Norepinephrine / pharmacology
Papaverine / pharmacology
Rats, Inbred Strains
Serotonin / pharmacology
Reg. No./Substance:
15078-28-1/Nitroprusside; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 51-45-6/Histamine; 51-83-2/Carbachol; 54-11-5/Nicotine; 58-74-2/Papaverine; 67-97-0/Cholecalciferol; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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