| Decrease in circulating dendritic cells predicts fatal outcome in septic shock. | |
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MedLine Citation:
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PMID: 17091240 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Biomarkers allowing accurate early staging of septic shock patients are lacking despite their obvious interest for patient management. Experimental models of septic shock in mouse previously noted a decrease in dendritic cell numbers. The aim of the study was to find a rapid reproducible biological test for an assessment of disease severity. DESIGN: Evaluation of peripheral blood dendritic cell counts by flow cytometry using three commercially available kits. PATIENTS AND PARTICIPANTS: Forty-two consecutive septic shock patients were studied prospectively. MEASUREMENTS AND RESULTS: Early low dendritic cell counts were correlated to disease severity as assessed by Simplified Acute Physiology Score or Sequential Organ Failure Assessment and predicted fatal outcome. The correlation was still present when the results were adjusted for age. CONCLUSION: The monitoring of blood dendritic cell count may provide an early and valuable assessment of the severity of the host response against infection and may influence the therapeutic management of septic shock patients. |
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Authors:
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Olivier Guisset; Marie-Sarah Dilhuydy; Rodolphe Thiébaut; Jérôme Lefèvre; Fabrice Camou; Anne Sarrat; Claude Gabinski; Jean-François Moreau; Patrick Blanco |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-11-08 |
Journal Detail:
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Title: Intensive care medicine Volume: 33 ISSN: 0342-4642 ISO Abbreviation: Intensive Care Med Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2007-01-15 Completed Date: 2007-07-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7704851 Medline TA: Intensive Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 148-52 Citation Subset: IM |
Affiliation:
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Département de Réanimation Médicale et Urgences, Hôpital St André, CHU de Bordeaux, Bordeaux, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Dendritic Cells* Female Humans Male Middle Aged Prognosis Prospective Studies Severity of Illness Index Shock, Septic / blood*, mortality* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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