| Decrease in circulating anti-angiogenic factors (angiostatin and endostatin) after surgical removal of primary colorectal carcinoma coincides with increased metabolic activity of liver metastases. | |
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MedLine Citation:
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PMID: 15674209 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Removal of a primary colorectal tumor resulted in an increase in metabolic activity in its liver metastasis. Concomitantly, levels of angiostatin and endostatin in urine and plasma, respectively, dropped. This finding indicates that the primary tumor suppressed angiogenesis in its distant metastasis, and that removal of the primary lesion caused a flare-up in vessel neoformation and, thus, enhanced metabolic activity in its liver metastasis. |
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Authors:
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Charlotte F J M Peeters; Lioe-Fee de Geus; Johan R Westphal; Robert M W de Waal; Dirk J Ruiter; Theo Wobbes; Wim J G Oyen; Theo J Ruers |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Surgery Volume: 137 ISSN: 0039-6060 ISO Abbreviation: Surgery Publication Date: 2005 Feb |
Date Detail:
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Created Date: 2005-01-27 Completed Date: 2005-03-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0417347 Medline TA: Surgery Country: United States |
Other Details:
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Languages: eng Pagination: 246-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Pathology 437, University Medical Center, PO Box 9101, Nijmegen 6500 HB, The Netherlands. c.peeters@pathol.umcn.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angiostatins / urine* Colorectal Neoplasms / metabolism, surgery* Endostatins / blood* Fluorodeoxyglucose F18 / diagnostic use Humans Liver Neoplasms / metabolism*, radionuclide imaging, secondary* Positron-Emission Tomography Radiopharmaceuticals / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Endostatins; 0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18; 86090-08-6/Angiostatins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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