| Decrease in beta-adrenergic receptors of lymphocytes in spontaneously occurring acute asthma. | |
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MedLine Citation:
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PMID: 8393400 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To clarify changes in beta-adrenergic receptor (BAR) density in spontaneously occurring acute asthma, BAR binding studies were performed on peripheral blood lymphocytes in eight asthmatic and ten normal subjects. Spirometry also was performed. Maximum binding capacity (Bmax) of BAR in acute asthma was significantly lower by 44.2 percent compared with that in stable asthma; FEV1/FVC ratio decreased by 23.9 percent. The Bmax for acute asthma also was significantly lower than that in normal subjects. The Bmax of BAR in all subjects was significantly correlated with FEV1/FVC ratio and percent FEV1. The percentage decrease in the FEV1/FVC ratio and FEV1 from the stable to acute state for each asthmatic subject did not correlate with corresponding percentage decrease in Bmax. These data demonstrate that BAR density of lymphocytes decreases substantially in acute asthma and, simultaneously, suggest that some factors other than the BAR mechanism contribute to the airway obstruction during acute asthma. |
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Authors:
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I Hataoka; M Okayama; M Sugi; H Inoue; T Takishima; K Shirato |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chest Volume: 104 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 1993 Aug |
Date Detail:
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Created Date: 1993-09-02 Completed Date: 1993-09-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 508-14 Citation Subset: AIM; IM |
Affiliation:
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First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adolescent Adult Aged Asthma / metabolism*, physiopathology Forced Expiratory Volume Humans Iodocyanopindolol Lymphocytes / metabolism* Male Middle Aged Pindolol / analogs & derivatives, metabolism Receptors, Adrenergic, beta / metabolism* Spirometry Vital Capacity |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Adrenergic, beta; 13523-86-9/Pindolol; 83498-72-0/Iodocyanopindolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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