Document Detail

Decrease in beta-adrenergic receptors of lymphocytes in spontaneously occurring acute asthma.
MedLine Citation:
PMID:  8393400     Owner:  NLM     Status:  MEDLINE    
To clarify changes in beta-adrenergic receptor (BAR) density in spontaneously occurring acute asthma, BAR binding studies were performed on peripheral blood lymphocytes in eight asthmatic and ten normal subjects. Spirometry also was performed. Maximum binding capacity (Bmax) of BAR in acute asthma was significantly lower by 44.2 percent compared with that in stable asthma; FEV1/FVC ratio decreased by 23.9 percent. The Bmax for acute asthma also was significantly lower than that in normal subjects. The Bmax of BAR in all subjects was significantly correlated with FEV1/FVC ratio and percent FEV1. The percentage decrease in the FEV1/FVC ratio and FEV1 from the stable to acute state for each asthmatic subject did not correlate with corresponding percentage decrease in Bmax. These data demonstrate that BAR density of lymphocytes decreases substantially in acute asthma and, simultaneously, suggest that some factors other than the BAR mechanism contribute to the airway obstruction during acute asthma.
I Hataoka; M Okayama; M Sugi; H Inoue; T Takishima; K Shirato
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chest     Volume:  104     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-09-02     Completed Date:  1993-09-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  508-14     Citation Subset:  AIM; IM    
First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
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MeSH Terms
Acute Disease
Asthma / metabolism*,  physiopathology
Forced Expiratory Volume
Lymphocytes / metabolism*
Middle Aged
Pindolol / analogs & derivatives,  metabolism
Receptors, Adrenergic, beta / metabolism*
Vital Capacity
Reg. No./Substance:
0/Receptors, Adrenergic, beta; 13523-86-9/Pindolol; 83498-72-0/Iodocyanopindolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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