Document Detail

Decrease in adrenal tyrosine hydroxylase and increase in norepinephrine synthesis in rats given L-dopa.
MedLine Citation:
PMID:  5542806     Owner:  NLM     Status:  MEDLINE    
When large doses of L-dopa (1000 milligrams per kilogram, given subcutaneously) were administered to rats, the rate of catecholamine synthesis was increased in both the heart and adrenal gland. It is likely that increases also occur in other sympathetically innervated tissues. When the same dose of L-dopa was given daily for 4 or 7 days, the levels of tyrosine hydroxylase in the adrenal were lowered in comparison to controls. These findings may be a further indication of the existence of a regulatory mechanism which modifies endogenous levels of tyrosine hydroxylase in response to changes in the biosynthetic demand for norepinephrine.
W Dairman; S Udenfriend
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  171     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1971 Mar 
Date Detail:
Created Date:  1971-03-30     Completed Date:  1971-03-30     Revised Date:  2011-12-13    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1022-4     Citation Subset:  IM    
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MeSH Terms
Adrenal Glands / enzymology*,  metabolism
Brain / enzymology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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