Document Detail

Decrease in FASN expression in adipose tissue of hypertensive individuals.
MedLine Citation:
PMID:  19851294     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Fatty acid (FA) synthesis enzymes (FA synthase (FASN) and acetyl-CoA carboxylase (ACC)) are related to metabolic alterations such as obesity, insulin resistance, or dyslipidemia. Due to the fact that there is no literature that relates FASN and ACC expression with hypertension, we investigate how FASN and ACC expression in adipose tissue is related to hypertension.
METHODS: This study included 87 patients, undergoing laparoscopic surgery procedures after an overnight fast. These patients were classified according to hypertension levels into two groups, normotensive and hypertensive, with a wide range of body mass index (BMI) in order to measure gene expression levels of FASN and ACC and anthropometric and biochemical variables.
RESULTS: The main result of this work is a significant decrease of FASN expression in adipose tissue of hypertensive vs. normotensive patients, and that FASN may predict systolic blood pressure (SBP) values by multiple regression analysis and there was also an inverse correlation between FASN expression and SBP.
CONCLUSIONS: In conclusion, to our knowledge it has been proven, for the first time, that there is a decrease of FASN expression in hypertensive individuals. The clinical significance of this work represents an exciting challenge because it would need to be clarified whether the reduced values of FASN expression may be associated with hypertension or whether this is an adaptive mechanism to the presence of hypertension. Once this aspect is clarified, it could be a new target for the treatment of hypertension.
María D Mayas; Francisco J Ortega; Ricardo Gómez-Huelgas; Nuria Roca; José M Fernández-Real; Francisco J Tinahones
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-10-22
Journal Detail:
Title:  American journal of hypertension     Volume:  22     ISSN:  1941-7225     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-20     Completed Date:  2010-01-25     Revised Date:  2011-06-30    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1258-62     Citation Subset:  IM    
Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario Virgen de Victoria de Málaga y CIBEROBN (CB06/03/010), Instituto de Salud Carlos III, Madrid, Spain.
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MeSH Terms
Acetyl-CoA Carboxylase / biosynthesis
Adipose Tissue / enzymology*
Blood Pressure
Fatty Acid Synthetase Complex / biosynthesis*
Gene Expression Regulation, Enzymologic
Hypertension / enzymology*
Middle Aged
Triglycerides / blood
Reg. No./Substance:
0/Triglycerides; EC 6.-/Fatty Acid Synthetase Complex; EC Carboxylase

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