| A Decrease in the Dose of Pegvisomant was Needed for the Treatment of Acromegaly after Adrenalectomy in a Patient with Coexisting Preclinical Cushing's Syndrome. | |
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MedLine Citation:
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PMID: 21921382 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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We herein describe the case of a 47-year-old woman with pre-clinical Cushing's syndrome caused by a left adrenal adenoma, which was diagnosed 6 years after trans-sphenoidal selective removal of a pituitary adenoma for acromegaly at age 35. The patient was started on bromocriptine and then somatostatin analogues after the surgery; however, since her serum insulin-like growth factor-1 (IGF-1) values remained above the age-adjusted normal range, the treatment for acromegaly was switched from somatostatin analogues to pegvisomant (10 mg daily), before a left laparoscopic adrenalectomy. After the subsequent adrenalectomy, the dose of pegvisomant could be reduced gradually to once every 4 days without any increase in the serum IGF-1 values. This is the first report describing the need for a different dose of pegvisomant for the treatment of acromegaly before and after adrenalectomy for pre-clinical Cushing's syndrome. |
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Authors:
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Atsushi Ogo; Yuka Matoba; Yayoi Matsuda; Shinsuke Hiramatsu |
Publication Detail:
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Type: Journal Article Date: 2011-09-15 |
Journal Detail:
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Title: Internal medicine (Tokyo, Japan) Volume: 50 ISSN: 1349-7235 ISO Abbreviation: Intern. Med. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-09-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204241 Medline TA: Intern Med Country: Japan |
Other Details:
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Languages: eng Pagination: 1987-91 Citation Subset: IM |
Affiliation:
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Department of Metabolism and Endocrinology, National Hospital Organization, Kyushu Medical Center, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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